TWIST1 and ZRANB1

Number of citations of the paper that reports this interaction (PubMedID 29748601)
1

Data Source:
BioGRID (enzymatic study)

		TWIST1	ZRANB1
Description		twist family bHLH transcription factor 1	zinc finger RANBP2-type containing 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding E-box Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Neural Tube Closure Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Regulation Of Bone Mineralization Positive Regulation Of Fatty Acid Beta-oxidation Developmental Process Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Histone Phosphorylation Negative Regulation Of Histone Acetylation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Outer Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Skeletal Muscle Tissue Development Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Cranial Suture Morphogenesis Embryonic Camera-type Eye Formation Eyelid Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Cell Motility Negative Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Cellular Senescence Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Double-strand Break Repair Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation	Cytoskeleton Organization Wnt Signaling Pathway Cell Migration Protein Deubiquitination Regulation Of Cell Morphogenesis Positive Regulation Of Wnt Signaling Pathway Protein K29-linked Deubiquitination Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Deubiquitination
Pathways		Interleukin-4 and Interleukin-13 signaling Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity	Degradation of beta-catenin by the destruction complex Ovarian tumor domain proteases
Drugs
Diseases		Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Coronary artery disease ( 30104761) Diastolic blood pressure ( 30578418) Diisocyanate-induced asthma ( 25918132) Ischemic stroke ( 29531354) Ischemic stroke (large artery atherosclerosis) ( 29531354) Male-pattern baldness ( 29146897) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 27841878 29403010 30487518 30578418) Stroke ( 29531354) Systolic blood pressure ( 27841878 30487518 30578418) Type 2 diabetes (age of onset) ( 28060188)	Blood urea nitrogen levels ( 31152163) Creatine kinase levels ( 29403010) Height ( 25429064 31562340)
Interacting Genes		24 interacting genes: BCL6 CHD4 EP300 GLI3 HOXA5 IKBKB KAT2B KMT5A KPNA5 KPNA7 MYOD1 NEIL3 PTEN RBBP7 RELA STAT3 TCF3 TCF4 TP53 TRIM28 YY1 YY2 ZIC3 ZRANB1	9 interacting genes: AKT1 CORO7 CSNK1A1 SNCA TRAF6 TWIST1 UBC UBE2S UVRAG
Entrez ID		7291	54764
HPRD ID		03374	11738
Ensembl ID		ENSG00000122691	ENSG00000019995
Uniprot IDs		Q15672	Q9UGI0
PDB IDs		2MJV	3ZRH 5AF6
Enriched GO Terms of Interacting Partners?
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