TRAF1 and ACTN3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRAF1	ACTN3
Description		TNF receptor associated factor 1	actinin alpha 3 (gene/pseudogene)
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Plasma Membrane Receptor Complex	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Exosome
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Ion Channel Binding
	Biological Process	Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Protein-containing Complex Assembly Protein K63-linked Ubiquitination Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle Filament Sliding Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway	Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Celiac disease or Rheumatoid arthritis ( 21383967) Lymphocyte counts ( 27863252) Pulse pressure ( 30578418) Rheumatoid arthritis ( 30891314 24782177 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		186 interacting genes: A1CF ABHD17A ACTN3 AKAP17A AQP1 ARNT2 ARSJ BARD1 BCAS2 BCL6 BEX2 BEX3 BIRC2 BIRC3 C1orf109 C1orf216 C2CD6 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCDC198 CCHCR1 CD40 CDCA3 CDKN1A CDKN2B CFLAR CHCHD3 CNTRL COX5B CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 EDAR EHHADH EWSR1 FAM161A FAM86C1P FBF1 FBXL18 FOSL2 GATA1 GATA2 GATAD2B GEM GFI1B GIT2 GLRX3 GMCL2 GNG5 GOLGA2 GORASP2 GRAP2 HAUS1 HEY2 HIVEP3 HMG20B HOXA1 HOXD12 IKBKB JOSD1 KIAA1217 KIF1A KLHL38 KPNA2 LATS1 LCOR LNX1 LNX2 LTBR MACIR MAP3K14 MAP6 MAPRE2 METTL17 MORN3 MOS MYEF2 NEBL NOL4L-DT NTAQ1 NUFIP2 NUP58 OLIG3 PBX3 PDE4D PHF21A PIN1 PKN1 PLAC8 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PRKAB2 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RIPK1 RIPK2 RNF31 RTP5 SCNM1 SDCBP2 SH3GLB2 SHARPIN SHFL SIK3 SLC25A48 SLC25A6 SNW1 SPG21 SPOP SRC SSC5D STK3 SUMO2 SYCE1 TANK TBC1D16 TCL1A TEAD4 TFAP4 TFPT THAP7 TICAM1 TIFA TLE5 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSSC4 USP7 WAC ZBTB1 ZBTB16 ZC2HC1C ZFYVE21 ZFYVE26 ZNF124 ZNF20 ZNF250 ZNF417 ZNF440 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF662 ZNF688 ZNF697	17 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A BRCA1 C1orf94 KCTD6 MYPN NEBL NRAP PLEKHG2 REL RNF111 SUMO1P1 TRAF1 TRAF2
Entrez ID		7185	89
HPRD ID		03418	02148
Ensembl ID		ENSG00000056558	ENSG00000248746
Uniprot IDs		Q13077	A0A087WSZ2 B4DZQ2 Q08043
PDB IDs		3M0D 5E1T 5H10	1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?
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