TRAF1 and PSMA1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRAF1	PSMA1
Description		TNF receptor associated factor 1	proteasome 20S subunit alpha 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Plasma Membrane Receptor Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Proteasome Core Complex Polysome Proteasome Core Complex, Alpha-subunit Complex Extracellular Exosome
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding	Lipopolysaccharide Binding RNA Binding Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding
	Biological Process	Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Protein-containing Complex Assembly Protein K63-linked Ubiquitination Regulation Of Extrinsic Apoptotic Signaling Pathway	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Amino Acid Metabolic Process Proteasomal Protein Catabolic Process Proteasomal Ubiquitin-independent Protein Catabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK - noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs			(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Celiac disease or Rheumatoid arthritis ( 21383967) Lymphocyte counts ( 27863252) Pulse pressure ( 30578418) Rheumatoid arthritis ( 30891314 24782177 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 31043756) Diastolic blood pressure ( 27841878) High chromosomal aberration frequency (total) ( 31586183) Systolic blood pressure ( 27841878) Vitamin D levels ( 25208829)
Interacting Genes		186 interacting genes: A1CF ABHD17A ACTN3 AKAP17A AQP1 ARNT2 ARSJ BARD1 BCAS2 BCL6 BEX2 BEX3 BIRC2 BIRC3 C1orf109 C1orf216 C2CD6 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCDC198 CCHCR1 CD40 CDCA3 CDKN1A CDKN2B CFLAR CHCHD3 CNTRL COX5B CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 EDAR EHHADH EWSR1 FAM161A FAM86C1P FBF1 FBXL18 FOSL2 GATA1 GATA2 GATAD2B GEM GFI1B GIT2 GLRX3 GMCL2 GNG5 GOLGA2 GORASP2 GRAP2 HAUS1 HEY2 HIVEP3 HMG20B HOXA1 HOXD12 IKBKB JOSD1 KIAA1217 KIF1A KLHL38 KPNA2 LATS1 LCOR LNX1 LNX2 LTBR MACIR MAP3K14 MAP6 MAPRE2 METTL17 MORN3 MOS MYEF2 NEBL NOL4L-DT NTAQ1 NUFIP2 NUP58 OLIG3 PBX3 PDE4D PHF21A PIN1 PKN1 PLAC8 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PRKAB2 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RIPK1 RIPK2 RNF31 RTP5 SCNM1 SDCBP2 SH3GLB2 SHARPIN SHFL SIK3 SLC25A48 SLC25A6 SNW1 SPG21 SPOP SRC SSC5D STK3 SUMO2 SYCE1 TANK TBC1D16 TCL1A TEAD4 TFAP4 TFPT THAP7 TICAM1 TIFA TLE5 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSSC4 USP7 WAC ZBTB1 ZBTB16 ZC2HC1C ZFYVE21 ZFYVE26 ZNF124 ZNF20 ZNF250 ZNF417 ZNF440 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF662 ZNF688 ZNF697	89 interacting genes: ABCD3 ABI3 ACTN1 APIP APP BLZF1 C11orf49 CALCOCO2 CBS CCDC102B CCDC85B CCNH CDA CEP70 CEP72 COIL DLEU1 EHMT2 GNPTAB GOLGA2 HOMER3 HSD17B14 IFT20 IKZF1 IKZF3 INO80E KCTD1 KCTD17 KCTD9 KRT15 KRT31 KRT38 KRT40 KRTAP5-9 LDB1 LDOC1 LZTS2 MAD1L1 MAPRE1 MAPRE3 MCM6 MID2 MKRN3 MLH1 MRFAP1L1 MT-CO2 MTUS2 NECAB2 NMI NOP53 NOTCH2NLA PLK1 PNMA1 PNMA2 PNMA5 POMP PPCDC PRDM14 PRKN PSMA2 PSMA3 PSMA4 PSMA7 PSMB1 PSMB10 PSMB2 PSMB5 RAD54B REL ROPN1 SFMBT1 SH3BP4 SH3GLB1 SSX2IP TCF12 TCF4 TDO2 TNFAIP1 TNR TRAF1 TRIM10 TRIM23 TRIM27 TRIM42 TSC22D4 UBXN11 VCP VIM ZFAND1
Entrez ID		7185	5682
HPRD ID		03418	04170
Ensembl ID		ENSG00000056558	ENSG00000129084
Uniprot IDs		Q13077	B4E0X6 P25786
PDB IDs		3M0D 5E1T 5H10	4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ
Enriched GO Terms of Interacting Partners?
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