KDM6A and NKX2-5

Number of citations of the paper that reports this interaction (PubMedID 22192413)
88

Data Source:
BioGRID (two hybrid)

		KDM6A	NKX2-5
Description		lysine demethylase 6A	NK2 homeobox 5
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	In Utero Embryonic Development Neural Tube Closure Heart Morphogenesis Respiratory System Process Chromatin Remodeling Positive Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Multicellular Organism Growth Mesodermal Cell Differentiation Notochord Morphogenesis Histone H3-K4 Methylation Oxidation-reduction Process Canonical Wnt Signaling Pathway Histone H3-K27 Demethylation Cardiovascular System Development	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Bundle Of His Development Purkinje Myocyte Differentiation Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Adult Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Sarcomere Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Heart Trabecula Formation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction
Pathways		HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors
Drugs
Diseases			Atrial septal defect Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG)
GWAS			Atrial fibrillation ( 30061737 29892015) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) Ischemic stroke (cardioembolic) ( 29531354) PR interval ( 30046033 20062060) Resting heart rate ( 27798624) Stroke ( 26089329)
Interacting Genes		9 interacting genes: H3-4 H3C1 H3C14 MTDH NKX2-5 SMAD9 SRF TBX5 TLE1	14 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A SRF TBX2 TBX5 TLE1
Entrez ID		7403	1482
HPRD ID		02131	02787
Ensembl ID		ENSG00000147050	ENSG00000183072
Uniprot IDs		B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 O15550 Q59HG3 Q86TD1	A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952
PDB IDs		3AVR 3AVS 6FUK 6FUL	3RKQ 4S0H
Enriched GO Terms of Interacting Partners?
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