KDM6A and TBX5

Number of citations of the paper that reports this interaction (PubMedID 22192413)
88

Data Source:
BioGRID (two hybrid)

		KDM6A	TBX5
Description		lysine demethylase 6A	T-box transcription factor 5
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	In Utero Embryonic Development Neural Tube Closure Heart Morphogenesis Respiratory System Process Chromatin Remodeling Positive Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Multicellular Organism Growth Mesodermal Cell Differentiation Notochord Morphogenesis Histone H3-K4 Methylation Oxidation-reduction Process Canonical Wnt Signaling Pathway Histone H3-K27 Demethylation Cardiovascular System Development	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Morphogenesis Of An Epithelium Bundle Of His Development Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Septum Development Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Atrial Septum Morphogenesis Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation
Pathways		HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors
Drugs
Diseases			Holt-Oram syndrome
GWAS			Airflow obstruction ( 22837378) Atrial fibrillation ( 28416818 28416822 30061737 29892015) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood pressure ( 21909110) Bone mineral density (total hip) ( 29883787) Diastolic blood pressure ( 28135244 19430479 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diverticular disease ( 30177863) Electrocardiographic traits ( 20062063) FEV1 ( 30804560) Hypertension ( 30487518) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Mean arterial pressure ( 30487518) Obesity-related traits ( 23251661) P wave duration ( 28794112) Peak expiratory flow ( 30804560) Percent mammographic density ( 22532574) PR interval ( 30046033 20062060 25035420 23139255 21347284) Prostate cancer ( 23535732 25939597) QRS duration ( 27577874 30012220 21076409) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Visceral fat ( 22589738)
Interacting Genes		9 interacting genes: H3-4 H3C1 H3C14 MTDH NKX2-5 SMAD9 SRF TBX5 TLE1	5 interacting genes: FBXO25 GATA4 KAT5 KDM6A NKX2-5
Entrez ID		7403	6910
HPRD ID		02131	03372
Ensembl ID		ENSG00000147050	ENSG00000089225
Uniprot IDs		B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 O15550 Q59HG3 Q86TD1	Q99593
PDB IDs		3AVR 3AVS 6FUK 6FUL	2X6U 2X6V 4S0H 5BQD
Enriched GO Terms of Interacting Partners?
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