ITGAL and F11R

Number of citations of the paper that reports this interaction (PubMedID 11812992)
148

Data Source:
HPRD (two hybrid, in vivo)

		ITGAL	F11R
Description		integrin subunit alpha L	F11 receptor
Image
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane Integrin AlphaL-beta2 Complex Specific Granule Membrane Extracellular Exosome	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Cell Junction Cytoplasmic Vesicle Protein-containing Complex Slit Diaphragm Extracellular Exosome Tight Junction
	Molecular Function	Protein Binding ICAM-3 Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding	Virus Receptor Activity Integrin Binding Protein Binding PDZ Domain Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phagocytosis Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Extracellular Matrix Organization Memory T Cell Extravasation Receptor Clustering Neutrophil Degranulation Regulation Of Immune Response Leukocyte Migration Cell-cell Adhesion	Regulation Of Cytokine Production Inflammatory Response Leukocyte Cell-cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Shape Response To Radiation Extracellular Matrix Organization Actomyosin Structure Organization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of GTPase Activity Positive Regulation Of Rho Protein Signal Transduction Memory T Cell Extravasation Positive Regulation Of GTPase Activity Positive Regulation Of Blood Pressure Viral Entry Into Host Cell Intestinal Absorption Leukocyte Migration Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Bicellular Tight Junction Assembly Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Positive Regulation Of Platelet Aggregation Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Actin Cytoskeleton Reorganization Regulation Of Bicellular Tight Junction Assembly
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Neutrophil degranulation RUNX3 Regulates Immune Response and Cell Migration	Cell surface interactions at the vascular wall Integrin cell surface interactions TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs		Efalizumab Antithymocyte immunoglobulin (rabbit) Lovastatin Simvastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline Lifitegrast
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil percentage of white cells ( 27863252) Smooth-surface caries ( 24556642) Ulcerative colitis ( 28067908 23128233) White blood cell count ( 27863252)	Inflammatory bowel disease ( 23128233) Night sleep phenotypes ( 27126917)
Interacting Genes		7 interacting genes: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN	16 interacting genes: AFDN ASIP BDNF CASK CGN CSNK2A1 F2RL2 ITGAL MPDZ PARD3 PEX19 PICK1 PRKCA PTPRB SGTA TJP1
Entrez ID		3683	50848
HPRD ID		01079	12038
Ensembl ID		ENSG00000005844	ENSG00000158769
Uniprot IDs		B2RAL6 P20701	Q6FIB4 Q9Y624
PDB IDs		1CQP 1DGQ 1IJ4 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2M3E 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX 4IXD 5E6R 5E6S 5E6U 6BXB 6BXF 6BXJ 6CKB	1NBQ 3EOY 3TSZ 4ODB
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?