THPO and APH1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		THPO	APH1A
Description		thrombopoietin	aph-1 homolog A, gamma-secretase subunit
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Mitochondrion Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex Integral Component Of Presynaptic Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Growth Factor Activity	Endopeptidase Activity Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Multicellular Organism Development Cell Proliferation Positive Regulation Of Cell Proliferation Megakaryocyte Development Thrombopoietin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade STAT Cascade Positive Regulation Of Hematopoietic Stem Cell Proliferation	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway
Pathways		Platelet Aggregation (Plug Formation)	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs			E-2012
Diseases
GWAS		Cardiometabolic and hematological traits ( 27668658) Diisocyanate-induced asthma ( 25918132) Platelet count ( 22139419 29403010 20139978 27863252) Plateletcrit ( 27863252)	Bipolar disorder ( 31043756) Chronotype ( 26955885) Morning vs. evening chronotype ( 26955885 26835600) Schizophrenia ( 25056061)
Interacting Genes		4 interacting genes: APH1A EP300 MPL NUMBL	17 interacting genes: ATF4 BHLHE40 CEP350 CREB3 GLP1R GPATCH8 HES1 HIVEP1 KLF11 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 THPO TLE1 TMED10
Entrez ID		7066	51107
HPRD ID		02500	06360
Ensembl ID		ENSG00000090534	ENSG00000117362
Uniprot IDs		A0A3B3ITS0 F8W6L1 P40225 Q5FBX8	B4DUG7 Q96BI3
PDB IDs		1V7M 1V7N	5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC
Enriched GO Terms of Interacting Partners?
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