TEC and PRLR

Number of citations of the paper that reports this interaction (PubMedID 11328862)
10

Data Source:
HPRD (in vivo, in vitro)

		TEC	PRLR
Description		tec protein tyrosine kinase	prolactin receptor
Image
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex
	Molecular Function	Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity JAK-STAT Cascade Embryo Implantation Lactation Response To Bacterium Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Positive Regulation Of Cold-induced Thermogenesis
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling	Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Fluoxymesterone
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)	Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		31 interacting genes: ARHGEF12 BMX BTK DOK1 ERBB2 FASLG FBXO7 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS	19 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 JAK2 MFGE8 NEK3 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		7006	5618
HPRD ID		02786	01457
Ensembl ID		ENSG00000135605	ENSG00000113494
Uniprot IDs		P42680	P16471
PDB IDs		2LUL	1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?
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