PRDX2 and EXOC6

Number of citations of the paper that reports this interaction (PubMedID 21163940)
33

Data Source:
BioGRID (two hybrid)

		PRDX2	EXOC6
Description		peroxiredoxin 2	exocyst complex component 6
Image			No pdb structure
GO Annotations	Cellular Component	Cell Cytoplasm Cytosol Extracellular Exosome	Exocyst Cytosol Plasma Membrane Membrane Growth Cone Perinuclear Region Of Cytoplasm Flemming Body
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity	Protein Binding
	Biological Process	Activation Of MAPK Activity Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Cellular Response To Stress Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Homeostasis Of Number Of Cells Oxidation-reduction Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs		3-Sulfinoalanine N-Carbamoyl-Alanine Copper
Diseases
GWAS			Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Body mass index ( 28892062) Coronary artery disease ( 29212778) Estimated glomerular filtration rate ( 31015462) Glaucoma (primary open-angle) ( 29449654) Hemoglobin A1c levels ( 29403010) High density lipoprotein cholesterol levels ( 29403010) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 30054594) Metabolic syndrome ( 31589552) Total bilirubin levels ( 29403010)
Interacting Genes		24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 TXNDC5 UTY YWHAZ	11 interacting genes: APP CYP2C8 ECSIT EXOSC1 GCDH LOXL4 MAST1 NOS3 PRDX2 PSEN2 RNF32
Entrez ID		7001	54536
HPRD ID		02763	10216
Ensembl ID		ENSG00000167815	ENSG00000138190
Uniprot IDs		P32119 V9HW12	A5YP36 B2RDH5 B3KXY5 B7Z6G5 E7EW84 Q8TAG9
PDB IDs		1QMV 5B8A 5B8B 5IJT
Enriched GO Terms of Interacting Partners?
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