TCF21 and HOXB6

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		TCF21	HOXB6
Description		transcription factor 21	homeobox B6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity Androgen Receptor Binding E-box Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Branching Structure Kidney Development Vasculature Development Regulation Of Transcription By RNA Polymerase II Sex Determination Branchiomeric Skeletal Muscle Development Epithelial Cell Differentiation Developmental Process Glomerulus Development Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Spleen Development Embryonic Digestive Tract Morphogenesis Reproductive Structure Development Gland Development Sertoli Cell Differentiation Roof Of Mouth Development Lung Morphogenesis Lung Vasculature Development Bronchiole Development Diaphragm Development Respiratory System Development Negative Regulation Of Androgen Receptor Signaling Pathway Metanephric Mesenchymal Cell Differentiation Metanephric Glomerular Capillary Formation	Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Erythrocyte Homeostasis Embryonic Skeletal System Morphogenesis
Pathways
Drugs
Diseases
GWAS		Blood pressure traits (multi-trait analysis) ( 28498854) Blood urea nitrogen levels ( 31152163) Coronary artery disease ( 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 22751097 21378990) Diastolic blood pressure ( 28498854) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Pulse pressure ( 28498854) Systolic blood pressure ( 28498854)	Childhood body mass index ( 26604143)
Interacting Genes		7 interacting genes: APEX1 APLP1 GTF3C5 HOXB6 KLF15 LMO4 TCF3	12 interacting genes: ALX4 CLK3 CREBBP CSNK2B EP300 HOXB7 KRT15 PKNOX1 PLSCR1 SAT1 TCEAL1 TCF21
Entrez ID		6943	3216
HPRD ID		04493	00849
Ensembl ID		ENSG00000118526	ENSG00000108511
Uniprot IDs		O43680	P17509
PDB IDs
Enriched GO Terms of Interacting Partners?
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