TBX15 and POLE2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TBX15	POLE2
Description		T-box transcription factor 15	DNA polymerase epsilon 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis
Pathways			Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases		Cousin syndrome
GWAS		Antitragus size ( 26105758) Birth weight ( 31043758) Body mass index ( 28892062 25673413) Breast size ( 27182965) Chin dimples ( 27182965) Congenital heart malformation ( 23708190) Ear morphology ( 26105758) Excessive hairiness ( 29895819) Facial morphology ( 31763980) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Folding of antihelix ( 26105758) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lung function (FVC) ( 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Male-pattern baldness ( 27182965 28196072) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 28552196) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412 28448500)
Interacting Genes		3 interacting genes: ATXN1 POLE2 VENTX	13 interacting genes: AGFG1 EEF1A1 ERG28 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 TBX15 TLE1 TRIM27
Entrez ID		6913	5427
HPRD ID		16035	16007
Ensembl ID		ENSG00000092607	ENSG00000100479
Uniprot IDs		Q8N8P2 Q96SF7	P56282
PDB IDs			2V6Z 5VBN
Enriched GO Terms of Interacting Partners?
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