POLE2 and ERG28

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		POLE2	ERG28
Description		DNA polymerase epsilon 2, accessory subunit	ergosterol biosynthesis 28 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle	Integral Component Of Membrane Transport Vesicle
	Molecular Function	DNA Binding Protein Binding	Molecular_function Protein Binding, Bridging
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	Biological_process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine
Diseases
GWAS
Interacting Genes		13 interacting genes: AGFG1 EEF1A1 ERG28 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 TBX15 TLE1 TRIM27	66 interacting genes: ALDH2 ANXA1 ANXA7 AQP2 BAIAP2 BID BTBD2 CCDC106 CCL18 CDC42 CDK5RAP2 CELF3 CLN8 COX17 CRADD CREB1 CREB3 CSTF2 DYNLL1 FAS FCGR2B FXR1 GADD45A GSK3B HMGB1 HNRNPH3 HNRNPUL1 HSPE1 HYLS1 KLHL20 LMNA LSM2 MAPK8IP2 MPHOSPH6 MRPL38 MRPS12 MTNR1B NAT9 NDUFA4L2 NR1H2 NSF PAFAH1B3 PCDHA4 PEX2 PFN1 PHYHIP POLE2 POLR2C POLR3F PPP1R8 PQBP1 RAB27A RPS6KA6 S100A8 SAT1 SEPHS1 SERPINB9 SNRPB SNRPG SULT1E1 TFG TK1 TSC22D1 TTR ZFP64 ZNF24
Entrez ID		5427	11161
HPRD ID		16007	05201
Ensembl ID		ENSG00000100479	ENSG00000133935
Uniprot IDs		P56282	Q6FII3 Q86TW5 Q9UKR5
PDB IDs		2V6Z 5VBN
Enriched GO Terms of Interacting Partners?
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