STAU1 and RASA1

Number of citations of the paper that reports this interaction (PubMedID 15121898)
60

Data Source:
HPRD (in vitro)

		STAU1	RASA1
Description		staufen double-stranded RNA binding protein 1	RAS p21 protein activator 1
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Microtubule Associated Complex Plasma Membrane Cytoplasmic Stress Granule Membrane Dendrite Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Cell Body Extracellular Exosome Glutamatergic Synapse	Ruffle Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Protein Phosphatase 1 Binding	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding
	Biological Process	Viral Process Cellular Response To Oxidative Stress Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Modification Of Postsynaptic Structure Positive Regulation Of Long-term Synaptic Potentiation	MAPK Cascade Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process
Pathways			Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases			RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Anger ( 24489884) Change in quality of life in response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease ( 31299468) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196 25282103) Intelligence (MTAG) ( 29326435) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Waist circumference adjusted for body mass index ( 28552196)	Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		40 interacting genes: APP CASC3 CDC42 CSNK2B DHX9 DYNC1I1 FMR1 GLRX3 HNRNPU INA IQGAP1 KIF2B LONRF1 MAP1B MAPT MYH1 NCBP1 NCL NXT1 PABPC1 PABPN1 PPP1CA PPP1CC RAC1 RASA1 ROCK2 RPL28 RPL6 RPL7A RPLP0 RPS6 SPP1 SRPK1 TAX1BP3 TINCR TUBB TUBB4A UBE2D3 UPF1 ZMAT3	75 interacting genes: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RACK1 RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		6780	5921
HPRD ID		03422	00745
Ensembl ID		ENSG00000124214	ENSG00000145715
Uniprot IDs		B3KRE0 O95793 Q59F99 Q6PJX3	P20936 Q59GK3
PDB IDs		4DKK 6HTU	1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS
Enriched GO Terms of Interacting Partners?
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