STAT4 and ADRB2

Number of citations of the paper that reports this interaction (PubMedID 24561123)
3

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		STAT4	ADRB2
Description		signal transducer and activator of transcription 4	adrenoceptor beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Lysosome Endosome Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Receptor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding	Amyloid-beta Binding Adrenergic Receptor Activity Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Epinephrine Binding Norepinephrine Binding
	Biological Process	Defense Response JAK-STAT Cascade Cytokine-mediated Signaling Pathway Interleukin-12-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Interleukin-35-mediated Signaling Pathway	Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Behavior Endosome To Lysosome Transport Response To Cold Positive Regulation Of Protein Kinase A Signaling Protein Deubiquitination Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Ubiquitination Heat Generation Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Membrane Organization Positive Regulation Of Mini Excitatory Postsynaptic Potential Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Autophagosome Maturation Positive Regulation Of Lipophagy Cellular Response To Amyloid-beta Response To Psychosocial Stress Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of AMPA Receptor Activity
Pathways		Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling	Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis ADORA2B mediated anti-inflammatory cytokines production
Drugs			Spermine Amphetamine Betaxolol Bethanidine Isoetarine Cabergoline Metoprolol Amitriptyline Olanzapine Atenolol Norepinephrine Mirtazapine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Trimipramine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoprenaline Arbutamine Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol NCX 950 Asenapine Droxidopa Bufuralol (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Tulobuterol Levosalbutamol
Diseases			Asthma
GWAS		Behcet's disease ( 23001997 23291587) Celiac disease ( 22057235 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Gamma glutamyl transferase levels ( 29403010) Generalized epilepsy ( 30531953) Hepatocellular carcinoma in hepatitis B infection ( 23242368) Idiopathic inflammatory myopathy ( 26362759) Inflammatory bowel disease ( 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Limited cutaneous systemic scleroderma ( 29293537) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Nontyphoidal Salmonella bacteraemia ( 29523850) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 23143596 24390342 20453841 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) SjÃ¶gren's syndrome ( 24097066 24097067 28076899) Systemic lupus erythematosus ( 27399966 24871463 26606652 23273568 26663301 23053960 26316170 26502338 18204098 21408207 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 28314753 24387989 21750679 31672989 20383147 29293537 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Vitiligo ( 27723757)	Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 27863252) Peak expiratory flow ( 30804560) Systolic blood pressure ( 29615537)
Interacting Genes		14 interacting genes: ADRB2 CREBBP CRK IL12RB1 IL12RB2 JUN MAP2K6 MAPK14 NMI PIAS2 SH2D1B STAT1 STAT3 ZNF467	92 interacting genes: ADGRG1 ADRB3 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 ARRDC3 CCKBR CD4 CD68 CD81 CD9 CEACAM1 CNN1 CSK EGLN3 EIF2B1 GMPR2 GNA11 GNA14 GNA15 GNAI2 GNAS GNAT2 GNB1 GNG2 GNL3L GPR37 GPRASP1 GPRC5B GRB2 GRIA3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 HDAC6 HTR4 IL1B IL6R INSR KCNE1 KCNJ6 KCNJ9 KCTD13 MAPK8IP2 MCAM MDM2 NEDD4 NOS1 OPRD1 PLA2G2D PRKCD PTGER1 RAB27A RAB3A RACK1 RAN RAP2C REL RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RNF41 SLC52A2 SLC9A3R1 SLC9A3R2 SNCG SRC STAT3 STAT4 TSG101 TSHR UCHL1 VAPA VDAC1 VDAC2 VEGFB WNK1
Entrez ID		6775	154
HPRD ID		02779	00187
Ensembl ID		ENSG00000138378	ENSG00000169252
Uniprot IDs		Q14765	P07550
PDB IDs			1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6MXT 6N48 6NI3 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6
Enriched GO Terms of Interacting Partners?
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