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SREBF2 and RAB11B
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
820
Data Source:
HPRD
(two hybrid)
SREBF2
RAB11B
Description
sterol regulatory element binding transcription factor 2
RAB11B, member RAS oncogene family
Image
GO Annotations
Cellular Component
Golgi Membrane
Nuclear Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
SREBP-SCAP-Insig Complex
Intracellular Membrane-bounded Organelle
Cell
Endosome
Cytosol
Synaptic Vesicle
Endomembrane System
Cell Junction
Phagocytic Vesicle Membrane
Phagocytic Vesicle
Recycling Endosome
Recycling Endosome Membrane
Extracellular Exosome
Anchored Component Of Synaptic Vesicle Membrane
Molecular Function
C-8 Sterol Isomerase Activity
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Protein Dimerization Activity
E-box Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Myosin V Binding
Cadherin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Cholesterol Metabolic Process
Cellular Response To Starvation
Positive Regulation Of Cholesterol Storage
SREBP Signaling Pathway
Response To Lipid
Cholesterol Homeostasis
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Receptor Recycling
Intracellular Protein Transport
Exocytosis
Melanosome Transport
Rab Protein Signal Transduction
Transferrin Transport
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Post-translational Protein Modification
Regulation Of Anion Transport
Constitutive Secretory Pathway
Regulated Exocytosis
Cellular Response To Acidic PH
Establishment Of Protein Localization To Membrane
Amyloid-beta Clearance By Transcytosis
Retrograde Transport, Endosome To Plasma Membrane
Regulation Of Protein Localization To Cell Surface
Regulation Of Endocytic Recycling
Pathways
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Regulation of cholesterol biosynthesis by SREBP (SREBF)
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
EGR2 and SOX10-mediated initiation of Schwann cell myelination
TBC/RABGAPs
RAB geranylgeranylation
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Birth weight (
31043758
27680694
)
General cognitive ability (
29844566
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
50 interacting genes:
ABLIM1
ABLIM2
ARHGEF1
ARRB1
ATF7IP
ATXN1
AURKA
CASP3
CASP8AP2
COPS5
CREB1
CREBBP
EGR1
EP300
FHL3
GOLGB1
HNF4A
HSPA5
INSIG1
INSIG2
ITGB4
KLF13
KPNB1
LINC00839
LZTR1
MAPK1
MAPK3
MRPS6
MTNR1B
NAE1
NFYA
NFYC
OS9
PIAS1
PIAS2
PIAS3
PSMD4
RAB11B
SCAP
SLC4A4
SMAD3
SP1
SPTBN1
SREBF1
SUMO1
TTC1
UBE2I
ZDHHC17
ZMYM2
ZYX
9 interacting genes:
APP
IKBKG
MYO5B
OPTN
RAB11FIP1
RAB11FIP2
RAB11FIP3
RAB11FIP5
SREBF2
Entrez ID
6721
9230
HPRD ID
02726
05009
Ensembl ID
ENSG00000198911
ENSG00000185236
Uniprot IDs
A0A024R1Q0
Q12772
Q15907
PDB IDs
1UKL
2F9L
2F9M
4OJK
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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