SREBF2 and ABLIM1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		SREBF2	ABLIM1
Description		sterol regulatory element binding transcription factor 2	actin binding LIM protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex Intracellular Membrane-bounded Organelle	Stress Fiber Cytoplasm Actin Cytoskeleton Lamellipodium
	Molecular Function	C-8 Sterol Isomerase Activity RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding	Actin Binding Protein Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Metabolic Process Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Response To Lipid Cholesterol Homeostasis Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion	Cytoskeleton Organization Visual Perception Animal Organ Morphogenesis Lamellipodium Assembly Cilium Assembly
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination	DCC mediated attractive signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 31043758 27680694) General cognitive ability ( 29844566) Schizophrenia ( 25056061 29483656)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Taste perception (total score including 6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965)
Interacting Genes		50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SREBF1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	21 interacting genes: ACTB ACTG1 APP BEGAIN CALCOCO2 CARD9 DAPK1 GOLGA2 HOOK2 KCNJ12 KRT15 LDOC1 LRRK2 MFHAS1 PTPRD SREBF2 TRAF2 TSC22D4 USHBP1 VIM YWHAG
Entrez ID		6721	3983
HPRD ID		02726	03819
Ensembl ID		ENSG00000198911	ENSG00000099204
Uniprot IDs		A0A024R1Q0 Q12772	B3KSG3 B4DQA3 O14639
PDB IDs		1UKL
Enriched GO Terms of Interacting Partners?
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