SPI1 and ETS2

Number of citations of the paper that reports this interaction (PubMedID 9681824)
31

Data Source:
BioGRID (pull down)

		SPI1	ETS2
Description		Spi-1 proto-oncogene	ETS proto-oncogene 2, transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Binding Protein Binding Transcription Factor Binding NFAT Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lymphoid Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Lymphocyte Differentiation Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Population Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Regression Pri-miRNA Transcription By RNA Polymerase II Interleukin-6-mediated Signaling Pathway Cellular Response To Ethanol Negative Regulation Of Histone H4 Acetylation Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis	Oncogene Induced Senescence
Drugs
Diseases		Acute myeloid leukemia (AML)
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood urea nitrogen levels ( 31152163) C-reactive protein levels ( 30388399) Estimated glomerular filtration rate ( 31152163) Experiencing mood swings ( 29500382) Familial squamous cell lung carcinoma ( 29924316) Global electrical heterogeneity phenotypes ( 29622589) Hematology traits ( 30576415) Intraocular pressure ( 29617998 25173106) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Medication use (diuretics) ( 31015401) Neuroticism ( 29255261)	Body mass index ( 25673413) C-reactive protein levels ( 30388399) Eye morphology ( 29921221) Fibrinogen levels ( 28107422) Fractures ( 30158200) Intraocular pressure ( 29617998) Non-small cell lung cancer (survival) ( 21079520) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260)
Interacting Genes		45 interacting genes: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF2 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 RUNX1 SIN3A SKI SPIB SSRP1 TBP TMX1	20 interacting genes: CDK10 COP1 CREBBP EP300 ERG ETS1 FOS GATA3 JUN NCOR1 NR3C1 POU5F1 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11
Entrez ID		6688	2114
HPRD ID		01305	01263
Ensembl ID		ENSG00000066336	ENSG00000157557
Uniprot IDs		P17947	P15036
PDB IDs			4BQA 4MHV
Enriched GO Terms of Interacting Partners?
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