SP3 and GCH1

Number of citations of the paper that reports this interaction (PubMedID 16696853)
14

Data Source:
BioGRID (two hybrid)

		SP3	GCH1
Description		Sp3 transcription factor	GTP cyclohydrolase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm PML Body Transcriptional Repressor Complex Protein-DNA Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Metal Ion Binding	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Coenzyme Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II B Cell Differentiation T Cell Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Cofactor Metabolic Process Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		SUMOylation of transcription factors	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Isopropyl Alcohol Guanine
Diseases			Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		End-stage renal disease in Type 1 diabetics ( 24029427) Lung cancer ( 28604730) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) QT interval ( 24952745) Sensation seeking ( 30718321)	Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)
Interacting Genes		23 interacting genes: AKT1 E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF NKX3-1 PIAS1 RB1 RBBP4 RPS20 SP1 STK19 SUMO1 TP53 TP73 UBE2I VEGFA ZBTB7A	14 interacting genes: AHSA1 ATP1B1 ATP6V1A CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ
Entrez ID		6670	2643
HPRD ID		03483	02573
Ensembl ID		ENSG00000172845	ENSG00000131979
Uniprot IDs		B7ZLN9 Q02447 Q59FX5 Q86TP0	A0A024R642 P30793 Q8IZH9
PDB IDs			1FB1
Enriched GO Terms of Interacting Partners?
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