GCH1 and ATP6V1A

		GCH1	ATP6V1A
Description		GTP cyclohydrolase 1	ATPase H+ transporting V1 subunit A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Cell Lysosomal Membrane Vacuolar Membrane Cytosol Plasma Membrane Microvillus Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome
	Molecular Function	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Coenzyme Binding Mitogen-activated Protein Kinase Binding	ATP Binding Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Cofactor Metabolic Process Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Cellular Response To Increased Oxygen Levels ATP Metabolic Process Phagosome Acidification Proton Transmembrane Transport
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Isopropyl Alcohol Guanine	Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases		Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)	Prostate cancer ( 23535732)
Interacting Genes		14 interacting genes: AHSA1 ATP1B1 ATP6V1A CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ	14 interacting genes: ANXA7 CD200R1L CDKN1A GCH1 GON4L KCNJ9 LPGAT1 LSAMP PPM1D RALGAPA1 SMN1 TK1 TMPRSS7 TUFM
Entrez ID		2643	523
HPRD ID		02573	06120
Ensembl ID		ENSG00000131979	ENSG00000114573
Uniprot IDs		A0A024R642 P30793 Q8IZH9	P38606
PDB IDs		1FB1
Enriched GO Terms of Interacting Partners?
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