GCH1 and RPH3A

Number of citations of the paper that reports this interaction (PubMedID 7802677)
9

Data Source:
HPRD (in vivo)

		GCH1	RPH3A
Description		GTP cyclohydrolase 1	rabphilin 3A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Golgi Apparatus Cytosol Synaptic Vesicle Extrinsic Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane Protein-containing Complex Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane
	Molecular Function	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Coenzyme Binding Mitogen-activated Protein Kinase Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Selenium Binding Rab GTPase Binding Phosphate Ion Binding Protein-containing Complex Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Cofactor Metabolic Process Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals	Intracellular Protein Transport Spontaneous Neurotransmitter Secretion
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Isopropyl Alcohol Guanine
Diseases		Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)	Alcohol consumption (max-drinks) ( 29460428) Body mass index ( 26426971) Chloride levels ( 29403010) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Low density lipoprotein cholesterol levels ( 29403010) Low HDL-cholesterol levels ( 31006500) Platelet count ( 22139419) Urate levels ( 31578528)
Interacting Genes		14 interacting genes: AHSA1 ATP1B1 ATP6V1A CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ	10 interacting genes: ADD2 CASK GCH1 NRXN1 RAB15 RAB27A RAB3A RAB3B RAB8A YWHAH
Entrez ID		2643	22895
HPRD ID		02573	15273
Ensembl ID		ENSG00000131979	ENSG00000089169
Uniprot IDs		A0A024R642 P30793 Q8IZH9	A0A024RBK6 Q9Y2J0
PDB IDs		1FB1
Enriched GO Terms of Interacting Partners?
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