SNRPN and GEMIN2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SNRPN	GEMIN2
Description		small nuclear ribonucleoprotein polypeptide N	gem nuclear organelle associated protein 2
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GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex U5 SnRNP U1 SnRNP U2 SnRNP U4 SnRNP Cytoplasm Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies
	Molecular Function	RNA Binding Protein Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Splicing Response To Hormone	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly MRNA Processing RNA Splicing Import Into Nucleus
Pathways		mRNA Splicing - Major Pathway	snRNP Assembly
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Aspartate aminotransferase levels ( 31219225) Carotid plaque burden ( 28282560) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Obesity-related traits ( 23251661) Panic disorder ( 31712720) Periodontal disease related phenotype (PCT5) ( 26962152) Periodontitis (DPAL) ( 24024966) Pulmonary function ( 17903307)	Vitamin D levels ( 28757204)
Interacting Genes		11 interacting genes: ARL4D CTBP1 FBL GEMIN2 GTF2I KEAP1 LRIF1 MAFG RBFOX1 SH3GL3 TP53	24 interacting genes: DDX20 DHX9 FBXO7 GEMIN5 IKBKG MTNR1A NUFIP1 RN7SL1 RNU1-1 RNU2-1 SMN1 SMN2 SNRNP70 SNRPD1 SNRPD2 SNRPD3 SNRPN SRSF1 SRSF2 SRSF3 SRSF4 STXBP2 STXBP3 U2AF2
Entrez ID		6638	8487
HPRD ID		01653	03999
Ensembl ID		ENSG00000128739	ENSG00000092208
Uniprot IDs		P63162 X5DP00	O14893
PDB IDs		5MF9	2LEH 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU
Enriched GO Terms of Interacting Partners?
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