SLC22A5 and PDZD3

Number of citations of the paper that reports this interaction (PubMedID 15553237)
12

Data Source:
HPRD (two hybrid)

		SLC22A5	PDZD3
Description		solute carrier family 22 member 5	PDZ domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome	Cytosol Plasma Membrane Brush Border Apical Junction Complex Apical Part Of Cell
	Molecular Function	Protein Binding ATP Binding Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding Xenobiotic Transmembrane Transporter Activity	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Ubiquitin-specific Protease Binding
	Biological Process	Sodium Ion Transport Response To Symbiotic Bacterium Quaternary Ammonium Group Transport Carnitine Transport Positive Regulation Of Intestinal Epithelial Structure Maintenance Sodium-dependent Organic Cation Transport Carnitine Transmembrane Transport Drug Transmembrane Export	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity
Pathways		Carnitine metabolism Organic cation transport Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)	Intestinal infectious diseases
Drugs		L-Carnitine
Diseases		Crohn's disease Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Acylcarnitine levels ( 26068415) Asthma ( 20860503 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Crohn's disease ( 28067908 21102463) Diastolic blood pressure ( 30578418) Fibrinogen ( 20031577) Height ( 20881960) Inflammatory bowel disease ( 28067908 23128233) Low density lipoprotein cholesterol levels ( 29083408) Mosquito bite size ( 28199695) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Serum metabolite levels ( 23093944) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: PDZD3 PDZK1 SLC9A3R1 SLC9A3R2	18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C NLRX1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7
Entrez ID		6584	79849
HPRD ID		04539	06191
Ensembl ID		ENSG00000197375	ENSG00000172367
Uniprot IDs		O76082	B0YJ61 Q86UT5
PDB IDs			2V90
Enriched GO Terms of Interacting Partners?
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