SLC12A3 and PDIA3

Number of citations of the paper that reports this interaction (PubMedID 11832422)
4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		SLC12A3	PDIA3
Description		solute carrier family 12 member 3	protein disulfide isomerase family A member 3
Image		No pdb structure
GO Annotations	Cellular Component	Cell Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Extracellular Space Cell Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Sodium:potassium:chloride Symporter Activity Sodium Ion Transmembrane Transporter Activity Sodium:chloride Symporter Activity Potassium:chloride Symporter Activity	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Identical Protein Binding
	Biological Process	Ion Transport Sodium Ion Transport Cell Volume Homeostasis Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Oxidation-reduction Process Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A3 causes Gitelman syndrome (GS)	ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Bendroflumethiazide Metolazone Benzthiazide Chlorothiazide Hydrochlorothiazide Diazoxide Polythiazide Quinethazone	Zinc Copper
Diseases
GWAS		HDL cholesterol ( 20031564 23505323) HDL cholesterol levels ( 26763881) Phoneme awareness ( 30741946)	Blood protein levels ( 30072576) Lead levels ( 26025379)
Interacting Genes		2 interacting genes: PDIA3 WNK4	20 interacting genes: APP BACE1 CALR CANX ERO1A ERP27 ESR1 FBLN5 GYPC HLA-A IFNG LGALS9 MDM2 MTNR1B SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A
Entrez ID		6559	2923
HPRD ID		02984	03625
Ensembl ID		ENSG00000070915	ENSG00000167004
Uniprot IDs		J3QSS1 P55017	P30101 V9HVY3
PDB IDs			2ALB 2DMM 2H8L 3F8U 6ENY
Enriched GO Terms of Interacting Partners?
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