PDIA3 and TAP1

Number of citations of the paper that reports this interaction (PubMedID 9545232)
30

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PDIA3	TAP1
Description		protein disulfide isomerase family A member 3	transporter 1, ATP binding cassette subfamily B member
Image
GO Annotations	Cellular Component	Extracellular Space Cell Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Centriolar Satellite MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Identical Protein Binding	Protein Binding ATP Binding Peptide Antigen-transporting ATPase Activity Peptide-transporting ATPase Activity ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity ADP Binding TAP1 Binding TAP2 Binding Peptide Transmembrane Transporter Activity
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Oxidation-reduction Process Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Protein Transport Peptide Transport Viral Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Transmembrane Transport Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Pathways		ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Zinc Copper
Diseases			Bare lymphocyte syndrome (BLS) type1 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Blood protein levels ( 30072576) Lead levels ( 26025379)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) IgA nephropathy ( 25305756) Metabolite levels ( 23823483) Nephropathy ( 21399633)
Interacting Genes		20 interacting genes: APP BACE1 CALR CANX ERO1A ERP27 ESR1 FBLN5 GYPC HLA-A IFNG LGALS9 MDM2 MTNR1B SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A	14 interacting genes: CREB3 ESR1 HLA-F HLA-G KRTAP4-12 LMNA MDFI MUL1 PDIA3 PSMB5 PSMB8 TAP2 TAPBP TDP2
Entrez ID		2923	6890
HPRD ID		03625	01359
Ensembl ID		ENSG00000167004	ENSG00000168394
Uniprot IDs		P30101 V9HVY3	A0A0S2Z5A6 B7Z7P4 Q03518
PDB IDs		2ALB 2DMM 2H8L 3F8U 6ENY	1JJ7 5U1D
Enriched GO Terms of Interacting Partners?
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