PDIA3 and IFNG

Number of citations of the paper that reports this interaction (PubMedID 8974399)
84

Data Source:
HPRD (in vivo)

		PDIA3	IFNG
Description		protein disulfide isomerase family A member 3	interferon gamma
Image
GO Annotations	Cellular Component	Extracellular Space Cell Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Identical Protein Binding	Cytokine Activity Interferon-gamma Receptor Binding Protein Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Oxidation-reduction Process Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Apoptotic Process Humoral Immune Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Positive Regulation Of Cell Proliferation Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Protein ADP-ribosylation Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Protein Complex Assembly Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway Regulation Of Growth Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Astrocyte Activation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Interleukin-1 Beta Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Neurogenesis Regulation Of Insulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Nitrogen Compound Metabolic Process Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate 1-phosphatase Activity Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Deacetylation Extrinsic Apoptotic Signaling Pathway Neuroinflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Neuron Death Positive Regulation Of Cellular Respiration Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Ferrous Iron Import Across Plasma Membrane Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of NMDA Glutamate Receptor Activity Positive Regulation Of Core Promoter Binding Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production
Pathways		ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Zinc Copper	Olsalazine Glucosamine VIR201 Fontolizumab Apremilast
Diseases			Graft-versus-host disease Allograft rejection
GWAS		Blood protein levels ( 30072576) Lead levels ( 26025379)	Alopecia areata ( 25608926) Anti-saccade response ( 29064472) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 20228799 21297633 19122664)
Interacting Genes		20 interacting genes: APP BACE1 CALR CANX ERO1A ERP27 ESR1 FBLN5 GYPC HLA-A IFNG LGALS9 MDM2 MTNR1B SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A	5 interacting genes: IFNGR1 IFNGR2 PDIA3 STAT6 TNF
Entrez ID		2923	3458
HPRD ID		03625	00957
Ensembl ID		ENSG00000167004	ENSG00000111537
Uniprot IDs		P30101 V9HVY3	P01579
PDB IDs		2ALB 2DMM 2H8L 3F8U 6ENY	1EKU 1FG9 1FYH 1HIG 3BES 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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