Wiki-CORONA
About
Search
Browse
Data Sources
People
Funding
Advanced Search
SKP1 and PTEN
Number of citations of the paper that reports this interaction (PubMedID
26561776
)
6
Data Source:
BioGRID
(pull down)
SKP1
PTEN
Description
S-phase kinase associated protein 1
phosphatase and tensin homolog
Image
GO Annotations
Cellular Component
Cell
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
PcG Protein Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Apical Plasma Membrane
PML Body
Myelin Sheath Adaxonal Region
Cell Projection
Neuron Projection
Dendritic Spine
Schmidt-Lanterman Incisure
Postsynaptic Membrane
Postsynaptic Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Phosphatidylinositol-3-phosphatase Activity
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Lipid Binding
Anaphase-promoting Complex Binding
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity
Enzyme Binding
PDZ Domain Binding
Ionotropic Glutamate Receptor Binding
Identical Protein Binding
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
Ubiquitin-specific Protease Binding
Protein Tyrosine Kinase Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Cellular Iron Ion Homeostasis
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Maintenance Of Protein Location In Nucleus
Interleukin-1-mediated Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Angiogenesis
Negative Regulation Of Protein Phosphorylation
Regulation Of B Cell Apoptotic Process
Transcription Initiation From RNA Polymerase II Promoter
Protein Dephosphorylation
Phosphatidylinositol Biosynthetic Process
Apoptotic Process
Neuron-neuron Synaptic Transmission
Synapse Assembly
Central Nervous System Development
Heart Development
Aging
Learning Or Memory
Memory
Locomotory Behavior
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Response To Glucose
Response To Zinc Ion
Positive Regulation Of Gene Expression
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Neuron Projection Development
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Activity
Cell Migration
Protein Deubiquitination
Dentate Gyrus Development
Central Nervous System Neuron Axonogenesis
Negative Regulation Of Cell Migration
Adult Behavior
Negative Regulation Of Myelination
Regulation Of Protein Stability
Regulation Of Synaptic Transmission, GABAergic
Central Nervous System Myelin Maintenance
Response To Estradiol
Regulation Of Cellular Component Size
Cellular Response To Insulin Stimulus
Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of Peptidyl-serine Phosphorylation
Response To ATP
Multicellular Organismal Response To Stress
Social Behavior
Peptidyl-tyrosine Dephosphorylation
Maternal Behavior
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Endothelial Cell Migration
Inositol Phosphate Metabolic Process
Cellular Response To Leptin Stimulus
Locomotor Rhythm
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Size
Negative Regulation Of Organ Growth
Response To Arsenic-containing Substance
Inositol Phosphate Dephosphorylation
Phosphatidylinositol Dephosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Negative Regulation Of Axon Regeneration
Cardiac Muscle Tissue Development
Forebrain Morphogenesis
Brain Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Phagocytosis
Negative Regulation Of Axonogenesis
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Keratinocyte Migration
Negative Regulation Of Focal Adhesion Assembly
Negative Regulation Of Protein Kinase B Signaling
Rhythmic Synaptic Transmission
Negative Regulation Of Cardiac Muscle Cell Proliferation
Canonical Wnt Signaling Pathway
Synapse Maturation
Prepulse Inhibition
Male Mating Behavior
Long-term Synaptic Potentiation
Long-term Synaptic Depression
Prostate Gland Growth
Dendritic Spine Morphogenesis
Negative Regulation Of Dendritic Spine Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Electrical Stimulus
Cellular Response To Ethanol
Cellular Response To Hypoxia
Negative Regulation Of Ribosome Biogenesis
Negative Regulation Of Cell Aging
Negative Regulation Of Excitatory Postsynaptic Potential
Presynaptic Membrane Assembly
Postsynaptic Density Assembly
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells
Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Ubiquitin Protein Ligase Activity
Negative Regulation Of Vascular Smooth Muscle Cell Proliferation
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Signaling Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Negative Regulation Of Synaptic Vesicle Clustering
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK - noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Negative regulation of the PI3K/AKT network
Downstream TCR signaling
TP53 Regulates Metabolic Genes
PTEN Loss of Function in Cancer
Ub-specific processing proteases
Ovarian tumor domain proteases
Regulation of PTEN mRNA translation
Regulation of PTEN localization
Regulation of PTEN stability and activity
Transcriptional Regulation by MECP2
Drugs
1-naphthaleneacetic acid
(2S)-2-(1H-indol-3-yl)hexanoic acid
(2S)-2-(1H-indol-3-yl)pentanoic acid
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
1H-INDOL-3-YLACETIC ACID
Phosphatidylethanolamine
Diseases
Vulvar cancer
Prostate cancer
Endometrial Cancer
Glioma
Small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Malignant melanoma
GWAS
Systemic lupus erythematosus (
27399966
26502338
)
Birth weight (
31043758
)
Eosinophil counts (
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Height (
31562340
)
Mercury levels (
26025379
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of granulocytes (
27863252
)
Periodontitis (Mean PAL) (
24024966
)
Psoriasis (
28537254
)
Pulse pressure (
27841878
)
Sum eosinophil basophil counts (
27863252
)
Thyroid stimulating hormone levels (
30367059
)
Type 2 diabetes (
24509480
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
White blood cell count (basophil) (
29403010
)
Interacting Genes
68 interacting genes:
ANKRD36BP1
APIP
BTRC
CACYBP
CAND1
CCNA2
CDCA3
CDK2
CDK4
CDK9
CDKN1A
CDKN1B
CENPE
CUL1
CUL7
DDX19B
FBH1
FBXL2
FBXL3
FBXL4
FBXL5
FBXL6
FBXL8
FBXO15
FBXO16
FBXO17
FBXO2
FBXO25
FBXO3
FBXO32
FBXO34
FBXO4
FBXO44
FBXO5
FBXO6
FBXO7
FBXO8
FBXO9
FBXW2
FBXW5
FBXW7
FBXW8
GHR
GLMN
GPS1
HSP90AA1
KCTD9
LMO2
MED21
MYC
NFKBIA
NFKBIB
NFKBIE
NUDT9P1
PPARGC1A
PPP1CA
PTEN
RBX1
SEC23B
SKP2
SUGT1
TBL1X
TERF1
TRRAP
TTC21A
TTC9C
UBE2D1
UHRF2
168 interacting genes:
AATK
AKAP12
AKT1
ANG
ANXA2
AR
ARF4
ATP5F1A
ATP5F1C
BCAR1
BEX1
CALM1
CAMK2G
CAV1
CCND2
CDC27
CFL1
CHGB
COPS6
CSNK1A1
CSNK2A1
CSNK2A2
CUL4B
CXCL1
DAXX
DBN1
DCAF11
DCAF13
DDB1
DLC1
DLG1
DNAJA1
DSP
EEF2
EPHA2
ERBB3
ESR1
FASN
FLNB
GNAI1
GNAI2
GNB4
GPC4
GSTM2
H2AC4
HBA1
HSD17B1
HSP90AB1
HSPA8
HSPD1
IL24
INS
ITPRID2
JUP
KBTBD4
LATS1
LDHB
LGALS1
LIMA1
LINC00839
MAGI2
MAGI3
MAP2K3
MAST1
MAST2
MAST3
MCRS1
METTL26
MME
MPRIP
MTHFD2
MVP
MYC
MYH10
MYL12A
MYO1B
MYO1C
MYO1D
MYOF
NCF1
NDFIP1
NGB
NME1
NUMB
OSGIN1
OTUD3
PARK7
PBK
PDGFRB
PELO
PKM
PLEC
PLK1
POLDIP2
PPL
PPP1CA
PRDX1
PSMD4
PTK2
PTK7
PXN
RCC2
RPL10A
RPL12
RPL13
RPL13A
RPL14
RPL22L1
RPL23
RPL27
RPL27A
RPL31
RPL38
RPL7
RPLP0
RPLP2
RPS13
RPS15A
RPS17
RPS2
RPS20
RPS25
RPS26
RPS27
RPS27A
RPS3
RPS4X
RPS6
RPS9
S100A8
S100A9
SDC1
SDC4
SDCBP
SETX
SIRT4
SKP1
SLC25A3
SLC25A5
SLC9A3R1
SLC9A3R2
SNAI1
SNTB2
SNX27
SPTAN1
SPTBN1
SSR4
STK11
STUB1
TNKS
TNKS2
TP53
TUBA1B
TUBB
TUBB4B
TUFM
TWIST1
TXN
UBE2I
UBE2L3
UBE2S
USP13
USP7
UTP14A
UTRN
WWP2
YAP1
YES1
Entrez ID
6500
5728
HPRD ID
03255
03431
Ensembl ID
ENSG00000113558
ENSG00000171862
Uniprot IDs
P63208
F6KD01
P60484
PDB IDs
1FQV
1FS1
1FS2
1LDK
1P22
2ASS
2AST
2E31
2E32
2OVP
2OVQ
2OVR
3L2O
3WSO
4I6J
5IBK
5JH5
5K35
5V4B
5VZT
5VZU
5XYL
6BVA
6BYH
6C16
6M90
6M91
6M92
6M93
6M94
6O60
1D5R
2KYL
4O1V
5BUG
5BZX
5BZZ
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?