PTEN and MME

Number of citations of the paper that reports this interaction (PubMedID 14749127)
42

Data Source:
BioGRID (imaging technique, pull down)

		PTEN	MME
Description		phosphatase and tensin homolog	membrane metalloendopeptidase
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Apical Plasma Membrane PML Body Myelin Sheath Adaxonal Region Cell Projection Neuron Projection Dendritic Spine Schmidt-Lanterman Incisure Postsynaptic Membrane Postsynaptic Cytosol	Cytoplasm Early Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Integral Component Of Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Lipid Binding Anaphase-promoting Complex Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Enzyme Binding PDZ Domain Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Ubiquitin-specific Protease Binding Protein Tyrosine Kinase Binding	Phosphatidylserine Binding Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Peptide Binding Protein Homodimerization Activity Oligopeptidase Activity Cardiolipin Binding
	Biological Process	Angiogenesis Negative Regulation Of Protein Phosphorylation Regulation Of B Cell Apoptotic Process Transcription Initiation From RNA Polymerase II Promoter Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Neuron-neuron Synaptic Transmission Synapse Assembly Central Nervous System Development Heart Development Aging Learning Or Memory Memory Locomotory Behavior Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Glucose Response To Zinc Ion Positive Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Cell Migration Protein Deubiquitination Dentate Gyrus Development Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell Migration Adult Behavior Negative Regulation Of Myelination Regulation Of Protein Stability Regulation Of Synaptic Transmission, GABAergic Central Nervous System Myelin Maintenance Response To Estradiol Regulation Of Cellular Component Size Cellular Response To Insulin Stimulus Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Peptidyl-serine Phosphorylation Response To ATP Multicellular Organismal Response To Stress Social Behavior Peptidyl-tyrosine Dephosphorylation Maternal Behavior Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Endothelial Cell Migration Inositol Phosphate Metabolic Process Cellular Response To Leptin Stimulus Locomotor Rhythm Positive Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Size Negative Regulation Of Organ Growth Response To Arsenic-containing Substance Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Cardiac Muscle Tissue Development Forebrain Morphogenesis Brain Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phagocytosis Negative Regulation Of Axonogenesis Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Keratinocyte Migration Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Kinase B Signaling Rhythmic Synaptic Transmission Negative Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Synapse Maturation Prepulse Inhibition Male Mating Behavior Long-term Synaptic Potentiation Long-term Synaptic Depression Prostate Gland Growth Dendritic Spine Morphogenesis Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Electrical Stimulus Cellular Response To Ethanol Cellular Response To Hypoxia Negative Regulation Of Ribosome Biogenesis Negative Regulation Of Cell Aging Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Postsynaptic Density Assembly Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Synaptic Vesicle Clustering	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Aging Learning Or Memory Sensory Perception Of Pain Lung Development Neutrophil Degranulation Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Negative regulation of the PI3K/AKT network Downstream TCR signaling TP53 Regulates Metabolic Genes PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2	Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation
Drugs		Phosphatidylethanolamine	Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat
Diseases		Vulvar cancer Prostate cancer Endometrial Cancer Glioma Small cell lung cancer Breast cancer Hepatocellular carcinoma Malignant melanoma
GWAS		Birth weight ( 31043758) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 31562340) Mercury levels ( 26025379) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Periodontitis (Mean PAL) ( 24024966) Psoriasis ( 28537254) Pulse pressure ( 27841878) Sum eosinophil basophil counts ( 27863252) Thyroid stimulating hormone levels ( 30367059) Type 2 diabetes ( 24509480) Type 2 diabetes (adjusted for BMI) ( 30297969) White blood cell count (basophil) ( 29403010)	Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878)
Interacting Genes		168 interacting genes: AATK AKAP12 AKT1 ANG ANXA2 AR ARF4 ATP5F1A ATP5F1C BCAR1 BEX1 CALM1 CAMK2G CAV1 CCND2 CDC27 CFL1 CHGB COPS6 CSNK1A1 CSNK2A1 CSNK2A2 CUL4B CXCL1 DAXX DBN1 DCAF11 DCAF13 DDB1 DLC1 DLG1 DNAJA1 DSP EEF2 EPHA2 ERBB3 ESR1 FASN FLNB GNAI1 GNAI2 GNB4 GPC4 GSTM2 H2AC4 HBA1 HSD17B1 HSP90AB1 HSPA8 HSPD1 IL24 INS ITPRID2 JUP KBTBD4 LATS1 LDHB LGALS1 LIMA1 LINC00839 MAGI2 MAGI3 MAP2K3 MAST1 MAST2 MAST3 MCRS1 METTL26 MME MPRIP MTHFD2 MVP MYC MYH10 MYL12A MYO1B MYO1C MYO1D MYOF NCF1 NDFIP1 NGB NME1 NUMB OSGIN1 OTUD3 PARK7 PBK PDGFRB PELO PKM PLEC PLK1 POLDIP2 PPL PPP1CA PRDX1 PSMD4 PTK2 PTK7 PXN RCC2 RPL10A RPL12 RPL13 RPL13A RPL14 RPL22L1 RPL23 RPL27 RPL27A RPL31 RPL38 RPL7 RPLP0 RPLP2 RPS13 RPS15A RPS17 RPS2 RPS20 RPS25 RPS26 RPS27 RPS27A RPS3 RPS4X RPS6 RPS9 S100A8 S100A9 SDC1 SDC4 SDCBP SETX SIRT4 SKP1 SLC25A3 SLC25A5 SLC9A3R1 SLC9A3R2 SNAI1 SNTB2 SNX27 SPTAN1 SPTBN1 SSR4 STK11 STUB1 TNKS TNKS2 TP53 TUBA1B TUBB TUBB4B TUFM TWIST1 TXN UBE2I UBE2L3 UBE2S USP13 USP7 UTP14A UTRN WWP2 YAP1 YES1	18 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 VIP
Entrez ID		5728	4311
HPRD ID		03431	00392
Ensembl ID		ENSG00000171862	ENSG00000196549
Uniprot IDs		F6KD01 P60484	P08473
PDB IDs		1D5R 2KYL 4O1V 5BUG 5BZX 5BZZ	1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2
Enriched GO Terms of Interacting Partners?
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