CSRNP1 and AQP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CSRNP1	AQP1
Description		cysteine and serine rich nuclear protein 1	aquaporin 1 (Colton blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Cell Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Symbiont-containing Vacuole Symbiont-containing Vacuole Membrane Brush Border Membrane Nuclear Membrane Sarcolemma Apical Part Of Cell Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Molecular_function DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Intracellular CGMP-activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Transmembrane Transporter Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Identical Protein Binding
	Biological Process	Apoptotic Process Post-embryonic Development Positive Regulation Of Transcription By RNA Polymerase II Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis	Renal Water Homeostasis Renal Water Transport Potassium Ion Transport Water Transport Cell Volume Homeostasis Hyperosmotic Response Cellular Water Homeostasis Carbon Dioxide Transport Ammonium Transport Bicarbonate Transport Glycerol Transport Cellular Homeostasis CGMP-mediated Signaling Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Odontogenesis Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Multicellular Organismal Water Homeostasis Cellular Response To Hydrogen Peroxide Cellular Response To Inorganic Substance Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport Maintenance Of Symbiont-containing Vacuole By Host
Pathways			Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs			Acetazolamide
Diseases
GWAS		Chronic lymphocytic leukemia ( 26956414) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Social communication problems ( 24564958)	Fractures ( 30598549) Heel bone mineral density ( 30598549 28869591) Huntington's disease progression ( 28642124) Kidney stones ( 31729369) Nephrolithiasis ( 22396660) Systolic blood pressure ( 30224653) Total body bone mineral density ( 29304378)
Interacting Genes		6 interacting genes: AQP1 PPP1CA PPP1CC TCEANC ZNF417 ZNF587	44 interacting genes: ADAMTSL4 CCDC136 CCDC57 CCDC85B CEP44 CREB3 CRTAC1 CSRNP1 EFEMP2 EPHB2 FOS FSD2 IHO1 IKZF2 IKZF3 KCTD17 KCTD9 KIAA1958 KRT31 KRT33B KRT40 KRTAP10-3 KRTAP10-7 KRTAP4-12 KRTAP4-2 KRTAP9-2 LMNA MDFI MID2 MTUS2 NBPF22P NOTCH2NLA PICK1 RGS17 RGS20 RIMBP3 SIAH1 SPRY2 TCF4 TNK2 TRAF1 TRAF2 TRIM23 TRIP6
Entrez ID		64651	358
HPRD ID		07347	00140
Ensembl ID		ENSG00000144655	ENSG00000240583
Uniprot IDs		Q96S65	A0A024RA31 P29972
PDB IDs			1FQY 1H6I 1IH5 4CSK 6POJ
Enriched GO Terms of Interacting Partners?
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