GMCL1 and IL17F

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GMCL1	IL17F
Description		germ cell-less 1, spermatogenesis associated	interleukin 17F
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Matrix	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Identical Protein Binding	Cytokine Activity Cytokine Receptor Binding Protein Binding Cytokine Binding Protein Homodimerization Activity
	Biological Process	Multicellular Organism Development Spermatogenesis Cell Differentiation	Inflammatory Response Negative Regulation Of Angiogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cytokine Biosynthetic Process Lymphotoxin A Biosynthetic Process Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Interleukin-8 Biosynthetic Process Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Interleukin-6 Secretion
Pathways			Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Atrial fibrillation ( 28416818 30061737 29892015) Colorectal or endometrial cancer ( 26621817) Whole brain grey matter density ( 31530798)	Initial alcohol sensitivity ( 30276832) Response to gemcitabine in pancreatic cancer ( 22142827) Survival in pancreatic cancer ( 28470677)
Interacting Genes		63 interacting genes: APLF APOL6 AXIN1 BYSL C5orf60 CCDC25 CFAP410 CHIC2 CIB3 CLK2 CUL3 ELOA EMD FKBP1B FOSL2 FOXR1 FRMD6 GAGE1 GAGE12B GAGE12I GAGE2E GAGE5 GLRX3 GMCL2 GOLGA2 GRAMD1A HYKK IL17F KAT5 KIFC3 KPNA2 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR NEBL NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PTPN7 QRICH1 RAD54B SHQ1 SLC15A3 SNX20 STK3 SUMO1 SUMO1P1 SYT17 TMPO TRIM13 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 ZNF250	2 interacting genes: GMCL1 RHOU
Entrez ID		64395	112744
HPRD ID		13587	16224
Ensembl ID		ENSG00000087338	ENSG00000112116
Uniprot IDs		Q53SE7 Q96IK5	Q96PD4
PDB IDs			1JPY 3JVF 5N92 5NAN 6HGO
Enriched GO Terms of Interacting Partners?
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