NSD1 and RORA

Number of citations of the paper that reports this interaction (PubMedID 23975195)
7

Data Source:
BioGRID (two hybrid)

		NSD1	RORA
Description		nuclear receptor binding SET domain protein 1	RAR related orphan receptor A
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K36 Methylation Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Regulation Of Peptidyl-serine Phosphorylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Angiogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Regulation Of Smoothened Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Cholesterol Homeostasis Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II CGMP Metabolic Process Negative Regulation Of Inflammatory Response Regulation Of Transcription Involved In Cell Fate Commitment Triglyceride Homeostasis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia T-helper 17 Cell Differentiation
Pathways		PKMTs methylate histone lysines	RORA activates gene expression RORA activates gene expression PPARA activates gene expression Nuclear Receptor transcription pathway Circadian Clock Circadian Clock SUMOylation of intracellular receptors Interleukin-4 and Interleukin-13 signaling
Drugs			Cholesterol-Sulfate Cholesterol
Diseases		Beckwith-Wiedemann syndrome Sotos syndrome and Weaver syndrome
GWAS		Activated partial thromboplastin time ( 22703881) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340) Narrowest width of the femoral neck ( 30888730) Nonsyndromic cleft lip ( 31609978) Urate levels ( 31578528) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult asthma ( 30787307) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Asthma ( 31361310 30929738 20860503 27182965 31619474 29273806) Asthma (adult onset) ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Birth weight ( 31043758) Blood protein levels ( 28240269) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 28892062) Breast cancer (prognosis) ( 23319801) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Chronic central serous retinopathy ( 30073298) Depression (quantitative trait) ( 20800221) Gamma glutamyl transferase levels ( 22010049) Height ( 31562340) High density lipoprotein cholesterol levels ( 31211820) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Male-pattern baldness ( 28196072) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Menarche (age at onset) ( 21102462 23599027 25231870) Multiple sclerosis ( 31604244) Neuropathic pain in head and neck cancer ( 29884837) Nickel levels ( 26025379) Offspring birth weight ( 31043758) Pulmonary function decline ( 22424883) Response to citalopram treatment ( 19846067) Schizophrenia ( 23212062) Subcutaneous adipose tissue ( 22589738) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		32 interacting genes: AR ATRX ESR1 ESRRA H1-2 H1-3 H1-5 H3-4 H3C1 H4-16 H4C1 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 NTRK3 POLR2A PPARG RARA RORA RORB RTN4 RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496	23 interacting genes: BHLHE41 COPS5 CSNK1E EP300 GFAP HIF1A LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 SP1 ZXDC
Entrez ID		64324	6095
HPRD ID		09455	02896
Ensembl ID		ENSG00000165671	ENSG00000069667
Uniprot IDs		Q96L73 Q96MN8	A0A0C4DFP5 A0A0C4DG53 P35398
PDB IDs		3OOI	1N83 1S0X 4S15
Enriched GO Terms of Interacting Partners?
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