RORA and GFAP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RORA	GFAP
Description		RAR related orphan receptor A	glial fibrillary acidic protein
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Cytoplasm Lysosome Cytosol Intermediate Filament Intermediate Filament Cytoskeleton
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding
	Biological Process	Angiogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Regulation Of Smoothened Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Cholesterol Homeostasis Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II CGMP Metabolic Process Negative Regulation Of Inflammatory Response Regulation Of Transcription Involved In Cell Fate Commitment Triglyceride Homeostasis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia T-helper 17 Cell Differentiation	Regulation Of Protein Complex Assembly Intermediate Filament Organization Regulation Of Chaperone-mediated Autophagy
Pathways		RORA activates gene expression RORA activates gene expression PPARA activates gene expression Nuclear Receptor transcription pathway Circadian Clock Circadian Clock SUMOylation of intracellular receptors Interleukin-4 and Interleukin-13 signaling	Nuclear signaling by ERBB4 Chaperone Mediated Autophagy
Drugs		Cholesterol-Sulfate Cholesterol
Diseases			Alexander disease
GWAS		Adult asthma ( 30787307) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Asthma ( 31361310 30929738 20860503 27182965 31619474 29273806) Asthma (adult onset) ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Birth weight ( 31043758) Blood protein levels ( 28240269) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 28892062) Breast cancer (prognosis) ( 23319801) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Chronic central serous retinopathy ( 30073298) Depression (quantitative trait) ( 20800221) Gamma glutamyl transferase levels ( 22010049) Height ( 31562340) High density lipoprotein cholesterol levels ( 31211820) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Male-pattern baldness ( 28196072) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Menarche (age at onset) ( 21102462 23599027 25231870) Multiple sclerosis ( 31604244) Neuropathic pain in head and neck cancer ( 29884837) Nickel levels ( 26025379) Offspring birth weight ( 31043758) Pulmonary function decline ( 22424883) Response to citalopram treatment ( 19846067) Schizophrenia ( 23212062) Subcutaneous adipose tissue ( 22589738) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)	Asthma ( 31619474) Cognitive function ( 25644384) Craniofacial microsomia ( 26853712)
Interacting Genes		23 interacting genes: BHLHE41 COPS5 CSNK1E EP300 GFAP HIF1A LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 SP1 ZXDC	51 interacting genes: AKT1 APP AURKB BIRC2 CAMK2A CDK1 CEP76 CFAP206 CRYAB FAM50B GOLGA2 GRAP2 HGS IKBKG KIAA0408 KRT13 KRT15 KRT19 LGALS14 LMO2 MEN1 MOS MYO15B NEFL NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SMARCB1 SRC STAT1 TLE5 TRIM27 TUBGCP4 UBE3A VIM ZC2HC1C
Entrez ID		6095	2670
HPRD ID		02896	00675
Ensembl ID		ENSG00000069667	ENSG00000131095
Uniprot IDs		A0A0C4DFP5 A0A0C4DG53 P35398	A7REI1 P14136
PDB IDs		1N83 1S0X 4S15	6A9P
Enriched GO Terms of Interacting Partners?
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