NSD1 and ZNF496

Number of citations of the paper that reports this interaction (PubMedID 15169884)
15

Data Source:
HPRD (two hybrid, in vitro)

		NSD1	ZNF496
Description		nuclear receptor binding SET domain protein 1	zinc finger protein 496
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K36 Methylation Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Regulation Of Peptidyl-serine Phosphorylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Positive Regulation Of Transcription, DNA-templated
Pathways		PKMTs methylate histone lysines	Generic Transcription Pathway
Drugs
Diseases		Beckwith-Wiedemann syndrome Sotos syndrome and Weaver syndrome
GWAS		Activated partial thromboplastin time ( 22703881) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340) Narrowest width of the femoral neck ( 30888730) Nonsyndromic cleft lip ( 31609978) Urate levels ( 31578528) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Chromium levels ( 26025379)
Interacting Genes		32 interacting genes: AR ATRX ESR1 ESRRA H1-2 H1-3 H1-5 H3-4 H3C1 H4-16 H4C1 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 NTRK3 POLR2A PPARG RARA RORA RORB RTN4 RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496	21 interacting genes: ARR3 CBX3 JADE2 NR3C1 NSD1 PGBD1 POLR3D PPARG RAI1 SNIP1 SSX3 SUMO2 SUPT5H TRIM28 ZKSCAN4 ZNF446 ZNF483 ZSCAN12 ZSCAN21 ZSCAN22 ZZZ3
Entrez ID		64324	84838
HPRD ID		09455	15805
Ensembl ID		ENSG00000165671	ENSG00000162714
Uniprot IDs		Q96L73 Q96MN8	Q96IT1
PDB IDs		3OOI
Enriched GO Terms of Interacting Partners?
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