PJA1 and ATXN3

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		PJA1	ATXN3
Description		praja ring finger ubiquitin ligase 1	ataxin 3
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GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body Synapse
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Regulatory Region DNA Binding Histone Deacetylase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity ATPase Binding Lys63-specific Deubiquitinase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Microtubule Cytoskeleton Organization Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Chemical Synaptic Transmission Nervous System Development Regulation Of Cell-substrate Adhesion Protein Deubiquitination Actin Cytoskeleton Organization Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Protein K63-linked Deubiquitination Histone H3 Deacetylation Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein Positive Regulation Of ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Schizophrenia ( 25056061 29483656)	Amyotrophic lateral sclerosis ( 29566793) Coronary artery calcification ( 23870195) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391950 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Orofacial clefts ( 22419666)
Interacting Genes		64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	50 interacting genes: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 C16orf70 CAPN1 CAPN2 CASP1 CDKN1A CHEK1 CSNK2B DNM2 EWSR1 GSK3B HDAC6 KAT2B MAP3K1 MKNK1 NCOR1 NEDD8 PICK1 PJA1 PRKN PSMD7 RAD23A RAD23B RFFL RPS6KA1 SMURF1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2L3 UBE2S UBE4B UBQLN1 USP21 VCP
Entrez ID		64219	4287
HPRD ID		02335	06131
Ensembl ID		ENSG00000181191	ENSG00000066427
Uniprot IDs		Q8NG27	A0A0A0MS38 C9JQV6 P54252
PDB IDs		2L0B	1YZB 2AGA 2DOS 2JRI 2KLZ 4WTH 4YS9
Enriched GO Terms of Interacting Partners?
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