SELP and SNX17

Number of citations of the paper that reports this interaction (PubMedID 11237770)
22

Data Source:
HPRD (two hybrid)

		SELP	SNX17
Description		selectin P	sorting nexin 17
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane	Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Lipopolysaccharide Binding Calcium Ion Binding Protein Binding Heparin Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Calcium-dependent Protein Binding Oligosaccharide Binding	Signaling Receptor Binding Protein Binding Protein C-terminus Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Platelet Degranulation Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Calcium-mediated Signaling Using Intracellular Calcium Source Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling Positive Regulation Of Leukocyte Tethering Or Rolling	Cardiac Septum Development Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Endosomal Transport Regulation Of Endocytosis Endocytic Recycling Aorta Development Coronary Vasculature Development Retrograde Transport, Endosome To Plasma Membrane
Pathways		Platelet degranulation Cell surface interactions at the vascular wall
Drugs		Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576 29875488 28240269) Hippocampal atrophy ( 22745009) Inflammatory bowel disease ( 26192919) Late-onset Alzheimer's disease ( 27770636) Optic disc size ( 31809533) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)	Alcohol use disorder (total score) ( 30336701) Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Microalbuminuria ( 31511532) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Urinary sodium to potassium ratio ( 30910378)
Interacting Genes		10 interacting genes: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN	11 interacting genes: ANXA2 APP HRAS LDLR LRP1 LRP2 LRP8 RLIM SELP SKIL VLDLR
Entrez ID		6403	9784
HPRD ID		01433	05812
Ensembl ID		ENSG00000174175	ENSG00000115234
Uniprot IDs		A0A024R8Y9 P16109 Q5R341 Q6NUL9	B4DDM3 B4DQ37 B4DTB8 Q15036
PDB IDs		1FSB 1G1Q 1G1R 1G1S 1HES 1KJD	3FOG 3LUI 4GXB 4TKN
Enriched GO Terms of Interacting Partners?
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