SCNN1A and EPN1

Number of citations of the paper that reports this interaction (PubMedID 16574660)
39

Data Source:
BioGRID (pull down)

		SCNN1A	EPN1
Description		sodium channel epithelial 1 subunit alpha	epsin 1
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Motile Cilium Sodium Channel Complex Ciliary Membrane Extracellular Exosome Sperm Principal Piece	Nucleus Cytosol Plasma Membrane Clathrin-coated Pit
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Protein Binding Lipid Binding
	Biological Process	Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis	In Utero Embryonic Development Endocytosis Notch Signaling Pathway Female Pregnancy Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Embryonic Organ Development Membrane Organization Negative Regulation Of Sprouting Angiogenesis
Pathways		Stimuli-sensing channels	EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Triamterene Amiloride	1,4-Diethylene Dioxide 1D-myo-inositol 1,4,5-trisphosphate
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Bronchiectasis with or without elevated sweat chloride
GWAS		Adverse response to drug ( 30420678) Alopecia areata ( 25608926) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity (early onset extreme) ( 23563609) Primary biliary cirrhosis ( 22961000)	Major depressive disorder ( 23377640)
Interacting Genes		18 interacting genes: COMMD10 CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L NPC2 SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2	24 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16
Entrez ID		6337	29924
HPRD ID		02575	06270
Ensembl ID		ENSG00000111319	ENSG00000063245
Uniprot IDs		P37088	A0A024R4S1 Q9Y6I3
PDB IDs		2M3O 6BQN	1INZ 1KYD
Enriched GO Terms of Interacting Partners?
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