ATXN2 and SH3GL3

  • Number of citations of the paper that reports this interaction (PubMedID 16713569)
  • 313
  • Data Source:
  • BioGRID (pull down, pull down, imaging technique)
  • HPRD (two hybrid, in vivo)

ATXN2

SH3GL3

Description ataxin 2 SH3 domain containing GRB2 like 3, endophilin A3
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Allergic disease (asthma, hay fever or eczema) ( 29083406)
  • Allergic rhinitis ( 30013184 31361310)
  • Alopecia areata ( 25608926)
  • Asthma ( 30929738)
  • Asthma (age of onset) ( 31036433)
  • Asthma (childhood onset) ( 31036433 30929738)
  • Asthma onset (childhood vs adult) ( 30929738)
  • Beta-2 microglubulin plasma levels ( 23417110)
  • Blood osmolality (transformed sodium) ( 28360221)
  • Blood pressure ( 21909110)
  • Body mass index ( 26426971)
  • Celiac disease ( 22057235 18311140)
  • Chronic kidney disease ( 20383146)
  • Coronary artery disease ( 29212778 30104761)
  • Crohn's disease ( 26192919 28067908)
  • Diastolic blood pressure ( 26390057 27736895 19430483)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Eosinophil counts ( 27863252)
  • Eosinophil percentage of granulocytes ( 27863252)
  • Eosinophil percentage of white cells ( 27863252)
  • Estimated glomerular filtration rate ( 31152163 31015462)
  • Gastroesophageal reflux disease ( 31527586)
  • Glaucoma (primary open-angle) ( 26752265)
  • Glomerular filtration rate (cystatin C) ( 28452372)
  • Glycated hemoglobin levels ( 28898252)
  • HDL cholesterol ( 30275531)
  • Heart failure ( 31919418)
  • Hematocrit ( 19862010)
  • High light scatter reticulocyte count ( 27863252)
  • High light scatter reticulocyte percentage of red cells ( 27863252)
  • Hypertension ( 31879980)
  • Hypothyroidism ( 27182965 22493691)
  • Immature fraction of reticulocytes ( 27863252)
  • Inflammatory bowel disease ( 26192919 28067908)
  • Intraocular pressure ( 30054594)
  • Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761)
  • LDL cholesterol ( 30275531)
  • Left ventricle diastolic internal dimension ( 28394258)
  • Mean arterial pressure ( 27618448)
  • Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Mean corpuscular volume ( 27863252)
  • Monocyte count ( 27863252)
  • Neutrophil percentage of granulocytes ( 27863252)
  • Parental longevity (combined parental age at death) ( 29227965)
  • Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
  • Parental longevity (father's age at death) ( 29227965)
  • Parental longevity (father's attained age) ( 29227965)
  • Parental longevity (mother's attained age) ( 29227965)
  • Peripheral artery disease ( 25009551)
  • Platelet count ( 24026423 29403010 27863252)
  • Platelet distribution width ( 27863252)
  • Plateletcrit ( 27863252)
  • Primary biliary cholangitis ( 26394269)
  • Primary biliary cirrhosis ( 22961000)
  • Primary sclerosing cholangitis ( 23603763)
  • Reaction time ( 29844566)
  • Red blood cell traits ( 23222517)
  • Reticulocyte fraction of red cells ( 27863252)
  • Retinal vascular caliber ( 21060863)
  • Sarcoidosis ( 26051272)
  • Serum total protein level ( 29403010)
  • Sjögren's syndrome ( 24097067)
  • Smoking initiation (ever regular vs never regular) ( 30679032)
  • Smoking status (ever vs never smokers) ( 30643258)
  • Sum eosinophil basophil counts ( 27863252)
  • Systemic lupus erythematosus ( 26502338 28714469)
  • Systolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Thyroid peroxidase antibody levels ( 24586183)
  • Thyroid peroxidase antibody positivity ( 24586183)
  • Total cholesterol levels ( 30275531)
  • Urate levels ( 31578528 23263486)
  • Vitiligo ( 27723757)
Interacting Genes 20 interacting genes: ACTN1 ACTN2 ATXN1 BAG6 BIN1 CHGB GFI1B GOLGA6L5P IDH3B IMPDH2 KIFBP LCP1 NCOA4 PABPC1 PLS3 RBFOX1 SH3GL2 SH3GL3 TDRD7 ZNRD1 47 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RBM48 RER1 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TNNT1 TOE1 VIM WASL WDR33
Entrez ID 6311 6457
HPRD ID 03307 04528
Ensembl ID ENSG00000204842 ENSG00000140600
Uniprot IDs F8VQP2 Q2M2R5 Q99700 A0A024R215 Q99963
PDB IDs 3KTR 2EW3 2Z0V
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?