MAPK12 and PTPN3

Number of citations of the paper that reports this interaction (PubMedID 20332238)
27

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		MAPK12	PTPN3
Description		mitogen-activated protein kinase 12	protein tyrosine phosphatase non-receptor type 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding
	Biological Process	MAPK Cascade DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Muscle Organ Development Regulation Of Gene Expression Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Intracellular Signal Transduction Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation DSCAM interactions VEGFA-VEGFR2 Pathway Myogenesis Myogenesis	EGFR downregulation
Drugs		Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin level ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114)
Interacting Genes		28 interacting genes: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1	18 interacting genes: ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 NXT2 RPS6KA1 VCP WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10
Entrez ID		6300	5774
HPRD ID		03868	06767
Ensembl ID		ENSG00000188130	ENSG00000070159
Uniprot IDs		P53778 Q6N076	B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs		1CM8 4QUM	2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS
Enriched GO Terms of Interacting Partners?
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