MAPK12 and RGS3

Number of citations of the paper that reports this interaction (PubMedID 16637659)
25

Data Source:
HPRD (in vitro)

		MAPK12	RGS3
Description		mitogen-activated protein kinase 12	regulator of G protein signaling 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleus Cytosol Plasma Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	MAPK Cascade DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Muscle Organ Development Regulation Of Gene Expression Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Intracellular Signal Transduction Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation	Inactivation Of MAPK Activity G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation DSCAM interactions VEGFA-VEGFR2 Pathway Myogenesis Myogenesis	G alpha (q) signalling events G alpha (i) signalling events
Drugs		Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)	Height ( 28552196)
Interacting Genes		28 interacting genes: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1	23 interacting genes: ACD APP CNKSR2 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		6300	5998
HPRD ID		03868	03720
Ensembl ID		ENSG00000188130	ENSG00000138835
Uniprot IDs		P53778 Q6N076	A0A024R831 A0A024R833 A0A024R841 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3
PDB IDs		1CM8 4QUM	2F5Y 2OJ4 3FBK
Enriched GO Terms of Interacting Partners?
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