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CLIP1 and MTOR
Number of citations of the paper that reports this interaction (PubMedID
12231510
)
32
Data Source:
HPRD
(in vivo)
CLIP1
MTOR
Description
CAP-Gly domain containing linker protein 1
mechanistic target of rapamycin kinase
Image
GO Annotations
Cellular Component
Kinetochore
Ruffle
Nuclear Envelope
Centrosome
Cytosol
Microtubule
Cytoplasmic Microtubule
Intermediate Filament
Microtubule Cytoskeleton
Cytoplasmic Vesicle Membrane
Microtubule Plus-end
Macropinosome
Golgi Membrane
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Cytosol
Endomembrane System
Membrane
PML Body
Dendrite
TORC1 Complex
TORC2 Complex
Neuronal Cell Body
Glutamatergic Synapse
Postsynaptic Cytosol
Molecular Function
Protein Binding
Microtubule Binding
Zinc Ion Binding
Tubulin Binding
Microtubule Plus-end Binding
RNA Polymerase III Type 1 Promoter DNA Binding
RNA Polymerase III Type 2 Promoter DNA Binding
RNA Polymerase III Type 3 Promoter DNA Binding
TFIIIC-class Transcription Factor Complex Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Kinase Binding
Protein Domain Specific Binding
Identical Protein Binding
Ribosome Binding
Translation Regulator Activity
Phosphoprotein Binding
Biological Process
Mitotic Cell Cycle
Microtubule Bundle Formation
Positive Regulation Of Microtubule Polymerization
Protein Transport Into Plasma Membrane Raft
Regulation Of Cell Growth
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
T-helper 1 Cell Lineage Commitment
Heart Morphogenesis
Heart Valve Morphogenesis
Regulation Of Glycogen Biosynthetic Process
Energy Reserve Metabolic Process
'de Novo' Pyrimidine Nucleobase Biosynthetic Process
Protein Phosphorylation
Cell Cycle Arrest
Germ Cell Development
Brain Development
Cell Aging
Response To Nutrient
Long-term Memory
Regulation Of Cell Size
Visual Learning
Cellular Response To Starvation
Post-embryonic Development
Negative Regulation Of Autophagy
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Neuron Maturation
Negative Regulation Of Muscle Atrophy
Response To Activity
Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Spinal Cord Development
Protein Catabolic Process
Positive Regulation Of Actin Filament Polymerization
Negative Regulation Of Protein Ubiquitination
Ruffle Organization
Regulation Of Myelination
Response To Nutrient Levels
Cellular Response To Nutrient Levels
TOR Signaling
Regulation Of Fatty Acid Beta-oxidation
Regulation Of Response To Food
Activation Of Protein Kinase B Activity
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Insulin
Regulation Of Actin Cytoskeleton Organization
Cellular Response To Amino Acid Starvation
Social Behavior
Multicellular Organism Growth
TORC1 Signaling
Wound Healing
Response To Cocaine
Regulation Of Circadian Rhythm
Regulation Of GTPase Activity
Response To Amino Acid
Anoikis
Response To Morphine
Regulation Of Carbohydrate Utilization
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Osteoclast Differentiation
Positive Regulation Of Translation
Negative Regulation Of Cell Size
Positive Regulation Of Transcription By RNA Polymerase III
Protein Autophosphorylation
Positive Regulation Of Lipid Biosynthetic Process
MRNA Stabilization
Rhythmic Process
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Voluntary Musculoskeletal Movement
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Keratinocyte Migration
Positive Regulation Of Protein Kinase B Signaling
Cardiac Muscle Cell Development
Cardiac Muscle Contraction
Maternal Process Involved In Female Pregnancy
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Dendritic Spine Development
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Stimulus
Cellular Response To Leucine
Cellular Response To Hypoxia
Regulation Of Brown Fat Cell Differentiation
Regulation Of Membrane Permeability
Regulation Of Translation At Synapse, Modulating Synaptic Transmission
Regulation Of Cellular Response To Heat
Positive Regulation Of Neuron Death
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Positive Regulation Of Eating Behavior
Positive Regulation Of Cholangiocyte Proliferation
Positive Regulation Of Sensory Perception Of Pain
Regulation Of Locomotor Rhythm
Negative Regulation Of Cholangiocyte Apoptotic Process
Positive Regulation Of Granulosa Cell Proliferation
Positive Regulation Of Skeletal Muscle Hypertrophy
Negative Regulation Of Iodide Transmembrane Transport
Positive Regulation Of Cytoplasmic Translational Initiation
Cellular Response To Leucine Starvation
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
PIP3 activates AKT signaling
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
Drugs
Pimecrolimus
Sirolimus
Everolimus
AP1903
SF1126
XL765
Temsirolimus
Diseases
GWAS
Body mass index (
26961502
25673413
)
Chronotype (
30696823
)
Hip circumference (
25673412
)
Weight (
28552196
)
Beard thickness (
26926045
)
Body mass index (
25673413
)
Corneal curvature (
24963161
)
Heel bone mineral density (
28869591
)
Interacting Genes
11 interacting genes:
BIN1
CALM1
CLASP2
DCTN1
IQGAP1
MAPRE2
MTOR
PAFAH1B1
TSC22D2
TUBA1A
TUBB
52 interacting genes:
AKT1
AKT1S1
AMBRA1
BCL2L1
C7orf25
CDC37
CFP
CLIP1
DCP2
EIF3F
EIF4EBP1
EIF4EBP2
EP300
ESR1
FBXO8
FKBP1A
FKBP8
GPHN
GSK3B
HRAS
IRS1
MAF1
MLST8
NRAS
PA2G4
PDPK1
PLD2
PPP2R2A
PREX1
PRKAA1
PRKCA
PRR5L
RHEB
RHEBL1
RICTOR
RPS6KA1
RPS6KB1
RPS6KB2
RPTOR
RRAGB
SEPTIN2
SKP2
STAT3
SUMO1
TELO2
TERT
TRAF6
UBQLN1
UVRAG
WIPI2
YWHAQ
ZNRF2
Entrez ID
6249
2475
HPRD ID
01568
03134
Ensembl ID
ENSG00000130779
ENSG00000198793
Uniprot IDs
A0A024RBR1
B3KXA5
P30622
P42345
PDB IDs
2CP5
2CP6
2E3H
2E3I
2E4H
2HQH
2QK0
3E2U
3RDV
1AUE
1FAP
1NSG
2FAP
2GAQ
2NPU
2RSE
3FAP
3JBZ
4DRH
4DRI
4DRJ
4FAP
4JSN
4JSP
4JSV
4JSX
4JT5
4JT6
5FLC
5GPG
5H64
5WBH
5WBU
5WBY
5ZCS
6BCU
6BCX
6SB0
6SB2
Enriched GO Terms of Interacting Partners
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