RPL18A and RNF115

Number of citations of the paper that reports this interaction (PubMedID 18819927)
35

Data Source:
BioGRID (two hybrid)

		RPL18A	RNF115
Description		ribosomal protein L18a	ring finger protein 115
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Polysomal Ribosome	Cytoplasm Cytosol
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Response To Antineoplastic Agent	Protein Polyubiquitination Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Breast cancer ( 25751625 29059683)
Interacting Genes		10 interacting genes: JUN LPL MAP3K12 MDK NEDD4 RIBC2 RNF115 RPL36 TLE5 TNK2	31 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2I UBE2N UBE2W USP9X VCP ZNRD2
Entrez ID		6142	27246
HPRD ID		16045	18328
Ensembl ID		ENSG00000105640	ENSG00000265491
Uniprot IDs		Q02543	Q9Y4L5
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
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