TNFRSF17 and ABCC1

		TNFRSF17	ABCC1
Description		TNF receptor superfamily member 17	ATP binding cassette subfamily C member 1
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GO Annotations	Cellular Component	Plasma Membrane Endomembrane System Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Activity	ATP Binding Organic Anion Transmembrane Transporter Activity Xenobiotic Transmembrane Transporting ATPase Activity Cobalamin-transporting ATPase Activity Glutathione S-conjugate-exporting ATPase Activity Efflux Transmembrane Transporter Activity ATPase Activity Lipid-transporting ATPase Activity Glutathione Transmembrane Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity
	Biological Process	Adaptive Immune Response Lymphocyte Homeostasis Signal Transduction Multicellular Organism Development Tumor Necrosis Factor-mediated Signaling Pathway	Leukotriene Metabolic Process Cobalamin Metabolic Process Cobalamin Transport Glutathione Transmembrane Transport Response To Drug Xenobiotic Transport Phospholipid Translocation Positive Regulation Of Inflammatory Response Transmembrane Transport Cell Chemotaxis Transepithelial Transport Leukotriene Transport Sphingolipid Translocation Export Across Plasma Membrane Cellular Response To Amyloid-beta
Pathways		TNFs bind their physiological receptors	Heme degradation Cobalamin (Cbl, vitamin B12) transport and metabolism Synthesis of Leukotrienes (LT) and Eoxins (EX) ABC-family proteins mediated transport
Drugs			ATP Sulfinpyrazone Biricodar dicitrate Romidepsin
Diseases
GWAS		Blood protein levels ( 30072576) Phenylephrine infusion rate during anesthesia ( 31455332) QT interval ( 19305408) Testicular germ cell tumor ( 26503584)	Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31152163) Ischemic stroke (undetermined subtype) ( 26708676) Multiple myeloma (survival) ( 26198393) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis proneness (perceptual aberration scale) ( 28525603) Rate of ventricular enlargement ( 31711042) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count (basophil) ( 27863252)
Interacting Genes		6 interacting genes: ABCC1 TNFSF13 TNFSF13B TRAF1 TRAF2 TRAF3	7 interacting genes: ATP5F1A AZGP1 CSNK2A1 NPM1 NR3C1 TNFRSF17 TRAF3
Entrez ID		608	4363
HPRD ID		00144	01153
Ensembl ID		ENSG00000048462	ENSG00000103222
Uniprot IDs		Q02223	P33527
PDB IDs		1OQD 1XU2 2KN1 4ZFO 6J7W	2CBZ 4C3Z
Enriched GO Terms of Interacting Partners?
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