ABCC1 and TRAF3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ABCC1	TRAF3
Description		ATP binding cassette subfamily C member 1	TNF receptor associated factor 3
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Extracellular Exosome	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Receptor Complex
	Molecular Function	ATP Binding Organic Anion Transmembrane Transporter Activity Xenobiotic Transmembrane Transporting ATPase Activity Cobalamin-transporting ATPase Activity Glutathione S-conjugate-exporting ATPase Activity Efflux Transmembrane Transporter Activity ATPase Activity Lipid-transporting ATPase Activity Glutathione Transmembrane Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding
	Biological Process	Leukotriene Metabolic Process Cobalamin Metabolic Process Cobalamin Transport Glutathione Transmembrane Transport Response To Drug Xenobiotic Transport Phospholipid Translocation Positive Regulation Of Inflammatory Response Transmembrane Transport Cell Chemotaxis Transepithelial Transport Leukotriene Transport Sphingolipid Translocation Export Across Plasma Membrane Cellular Response To Amyloid-beta	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Deubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Defense Response To Virus Protein K63-linked Ubiquitination
Pathways		Heme degradation Cobalamin (Cbl, vitamin B12) transport and metabolism Synthesis of Leukotrienes (LT) and Eoxins (EX) ABC-family proteins mediated transport	TRAF3 deficiency - HSE TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ovarian tumor domain proteases TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs		ATP Sulfinpyrazone Biricodar dicitrate Romidepsin
Diseases
GWAS		Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31152163) Ischemic stroke (undetermined subtype) ( 26708676) Multiple myeloma (survival) ( 26198393) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis proneness (perceptual aberration scale) ( 28525603) Rate of ventricular enlargement ( 31711042) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count (basophil) ( 27863252)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma (childhood onset) ( 30929738) Body mass index ( 25673413 29273807) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Eczema ( 31361310) Gallstone disease ( 30692554) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 28714469)
Interacting Genes		7 interacting genes: ATP5F1A AZGP1 CSNK2A1 NPM1 NR3C1 TNFRSF17 TRAF3	61 interacting genes: ABCC1 ALPL APOBEC3C AZI2 BEX3 BIRC3 CASP3 CD27 CD40 CELF2 CSNK1E DAXX EDA2R EDAR EWSR1 FAS GRIN1 GRIN2D HNRNPC IL15 IRF1 LTBR MAP2K1 MAP3K14 MAP3K7 NUP62 OTUD5 PDLIM7 RIPK1 RNF216 RRAS2 SAR1A SRC STK38 TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZMYND11
Entrez ID		4363	7187
HPRD ID		01153	03539
Ensembl ID		ENSG00000103222	ENSG00000131323
Uniprot IDs		P33527	A6NHG8 Q13114
PDB IDs		2CBZ 4C3Z	1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
Enriched GO Terms of Interacting Partners?
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