PAPPA2 and ATF7IP

Number of citations of the paper that reports this interaction (PubMedID 15231748)
85

Data Source:
HPRD (two hybrid)

		PAPPA2	ATF7IP
Description		pappalysin 2	activating transcription factor 7 interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Apical Plasma Membrane Extracellular Exosome	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Nuclear Body
	Molecular Function	Metallopeptidase Activity Zinc Ion Binding	Transcription Corepressor Activity Protein Binding ATPase Activity
	Biological Process	Regulation Of Cell Growth Proteolysis Response To Salt Stress Cellular Protein Metabolic Process Bone Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Viral Process Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Protein Stabilization Positive Regulation Of Methylation-dependent Chromatin Silencing
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Automobile speeding propensity ( 30643258) Birth weight ( 31043758) Body mass index ( 26426971) Fractional exhaled nitric oxide (childhood) ( 24315451) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Height ( 20881960 25429064 31562340) Offspring birth weight ( 31043758) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulse pressure ( 27841878 30578418) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240)
Interacting Genes		5 interacting genes: ATF7IP IGFBP3 IGFBP5 SMAD4 ZNF512B	69 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		60676	55729
HPRD ID		10156	09811
Ensembl ID		ENSG00000116183	ENSG00000171681
Uniprot IDs		Q9BXP8	A0A024RAY1 B3KNI7 B3KQF8 Q6VMQ6
PDB IDs			2RPQ
Enriched GO Terms of Interacting Partners?
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