PAPPA2 and IGFBP5

Number of citations of the paper that reports this interaction (PubMedID 11264294)
61

Data Source:
HPRD (in vitro)

		PAPPA2	IGFBP5
Description		pappalysin 2	insulin like growth factor binding protein 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Apical Plasma Membrane Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	Metallopeptidase Activity Zinc Ion Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Regulation Of Cell Growth Proteolysis Response To Salt Stress Cellular Protein Metabolic Process Bone Morphogenesis	Regulation Of Cell Growth Osteoblast Differentiation Signal Transduction Female Pregnancy Aging Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Growth Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Response To Growth Hormone Cellular Response To CAMP Cellular Response To Organic Cyclic Compound Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Hypertrophy Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Automobile speeding propensity ( 30643258) Birth weight ( 31043758) Body mass index ( 26426971) Fractional exhaled nitric oxide (childhood) ( 24315451) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Height ( 20881960 25429064 31562340) Offspring birth weight ( 31043758) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulse pressure ( 27841878 30578418) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Blood protein levels ( 30072576 29875488) Breast cancer ( 29059683) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hypothyroidism ( 27182965) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Pulse pressure ( 27841878) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid hormone levels ( 23408906) Visceral fat ( 22589738)
Interacting Genes		5 interacting genes: ATF7IP IGFBP3 IGFBP5 SMAD4 ZNF512B	21 interacting genes: ADAM12 BAG6 CREB3 CSDE1 F2 FHL2 FN1 IGF1 IGF2 IGFALS KPNB1 LMNA LTBP1 PAPPA2 PNO1 RASSF1 SERPINE1 SPP1 TF THBS1 VTN
Entrez ID		60676	3488
HPRD ID		10156	00901
Ensembl ID		ENSG00000116183	ENSG00000115461
Uniprot IDs		Q9BXP8	P24593
PDB IDs			1BOE 1H59
Enriched GO Terms of Interacting Partners?
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