ALX4 and ALX1

Number of citations of the paper that reports this interaction (PubMedID 9847249)
31

Data Source:
HPRD (in vitro)

		ALX4	ALX1
Description		ALX homeobox 4	ALX homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Golgi Apparatus Nuclear Body
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Skeletal System Development Hair Follicle Development Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Embryonic Skeletal System Morphogenesis Roof Of Mouth Development	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Neural Crest Cell Migration Neural Tube Closure Transcription By RNA Polymerase II Multicellular Organism Development Anterior/posterior Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Embryonic Limb Morphogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Roof Of Mouth Development
Pathways
Drugs
Diseases		Frontonasal dysplasia Enlarged parietal foramina/cranium bifidum	Frontonasal dysplasia
GWAS		Blood pressure measurement (high sodium intervention) ( 24165912) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) Gout ( 22179738) Male-pattern baldness ( 29146897 27182965) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Bone mineral density (Ward's triangle area) ( 27397699) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Nonsyndromic cleft lip ( 31609978) Nose size ( 27182965)
Interacting Genes		12 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2	5 interacting genes: ALX4 CREBBP EP300 IPO13 SRA1
Entrez ID		60529	8092
HPRD ID		05661	03316
Ensembl ID		ENSG00000052850	ENSG00000180318
Uniprot IDs		Q9H161	Q15699 V9HWA7
PDB IDs		2M0C
Enriched GO Terms of Interacting Partners?
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