ALX4 and HOXB13

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		ALX4	HOXB13
Description		ALX homeobox 4	homeobox B13
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex	Nuclear Chromatin Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Methyl-CpG Binding Sequence-specific DNA Binding
	Biological Process	Skeletal System Development Hair Follicle Development Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Embryonic Skeletal System Morphogenesis Roof Of Mouth Development	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Epidermis Development Response To Wounding Response To Testosterone Regulation Of Growth Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development
Pathways
Drugs
Diseases		Frontonasal dysplasia Enlarged parietal foramina/cranium bifidum
GWAS		Blood pressure measurement (high sodium intervention) ( 24165912) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) Gout ( 22179738) Male-pattern baldness ( 29146897 27182965) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Prostate cancer ( 23104005 23535732)
Interacting Genes		12 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2	8 interacting genes: ALX4 ELK1 HOXD4 IRF4 MEIS1 POU2F1 RAB5C ZNF490
Entrez ID		60529	10481
HPRD ID		05661	05210
Ensembl ID		ENSG00000052850	ENSG00000159184
Uniprot IDs		Q9H161	Q4KR72 Q92826
PDB IDs		2M0C	2CRA 5EDN 5EEA 5EF6 5EG0 5EGO 5NO6
Enriched GO Terms of Interacting Partners?
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