NIF3L1 and GNMT

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NIF3L1	GNMT
Description		NGG1 interacting factor 3 like 1	glycine N-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Cytosol
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding
	Biological Process	Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process
Pathways			Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation
Drugs			Ademetionine Glycine S-adenosyl-L-homocysteine Citric Acid
Diseases			Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Triptolide cytotoxicity ( 26121980)	Blood protein levels ( 30072576 29875488) Plasma homocysteine levels (post-methionine load test) ( 24651765)
Interacting Genes		67 interacting genes: AP5B1 APIP ARPIN BEND7 CCDC102B CCDC85B CDKN2B CDKN2C COIL COPS2 CUTC CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DUSP23 DYNLT3 EIF5A2 ENOX1 EPHB6 FXR2 GNMT GRB2 KCTD17 KRT15 KXD1 LAMTOR3 LMO2 MAGEA11 MAPRE2 MLXIPL NATD1 NME1 NOL3 NUDT14 NUDT21 ORC5 PAICS PCBD1 PNMA1 PRTFDC1 RABAC1 RAD54B RPIA S100A1 SAT1 SNF8 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SYT17 THOC7 TIFA TRAF2 TRIM21 TRIM27 TRIP13 TSC22D4 VIM YES1 YWHAQ ZBED1	19 interacting genes: ADAMTSL4 ARR3 ARRB1 HDAC7 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP TERF1 TERF2 TERF2IP TINF2
Entrez ID		60491	27232
HPRD ID		10424	05970
Ensembl ID		ENSG00000196290	ENSG00000124713
Uniprot IDs		A0A024R3V5 A0A024R3V7 Q9GZT8	A0A0S2Z5F2 Q14749 V9HW60
PDB IDs			1R74 2AZT
Enriched GO Terms of Interacting Partners?
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