GNMT and KRTAP4-2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GNMT	KRTAP4-2
Description		glycine N-methyltransferase	keratin associated protein 4-2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytosol Keratin Filament
	Molecular Function	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	Protein Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process	Keratinization
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation	Keratinization
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine Citric Acid
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Blood protein levels ( 30072576 29875488) Plasma homocysteine levels (post-methionine load test) ( 24651765)
Interacting Genes		19 interacting genes: ADAMTSL4 ARR3 ARRB1 HDAC7 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP TERF1 TERF2 TERF2IP TINF2	75 interacting genes: ADAMTSL4 ALDH3B1 AMOTL2 AQP1 ATG9A AXIN1 BYSL CHIC2 CHRD CRCT1 CREB5 DLGAP2 DOCK2 FAM74A4 GLRX3 GNMT HOXA1 HPCAL1 HSD3B7 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP26-1 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1B LCE2A LCE3C LCE3E LCE4A LNX1 MEOX2 NECTIN3 NLK NOTCH2NLA NR1D2 NTAQ1 NUFIP2 OTX1 PDE9A PGLS PIN1 PLSCR1 POM121L8P PRKAB2 PRKAG1 PSMA6 RASSF5 RGS20 SDC3 SHFL SLC23A1 SLC25A10 SPATA24 SPATA3 SPRY1 TCEANC TINAGL1 TRIM42 TXNDC5 TYRO3 ZBTB24 ZNF124 ZNF20 ZNF417 ZNF559 ZNF581 ZNF688
Entrez ID		27232	85291
HPRD ID		05970	13944
Ensembl ID		ENSG00000124713	ENSG00000244537
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	Q9BYR5
PDB IDs		1R74 2AZT
Enriched GO Terms of Interacting Partners?
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