NIF3L1 and CDKN2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NIF3L1	CDKN2B
Description		NGG1 interacting factor 3 like 1	cyclin dependent kinase inhibitor 2B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Negative Regulation Of Cell Proliferation Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Extracellular Stimulus Cellular Response To Nutrient Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Negative Regulation Of Epithelial Cell Proliferation Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs
Diseases			Malignant pleural mesothelioma Osteosarcoma Type II diabetes mellitus
GWAS		Triptolide cytotoxicity ( 26121980)	Ankle-brachial index ( 22199011) Basal cell carcinoma ( 24403052 25855136 27539887) Breast cancer ( 29059683 23535729 20453838) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Carotid plaque burden ( 28282560) Chronic lymphocytic leukemia ( 23770605) Coronary artery calcification ( 22144573 23561647) Coronary artery disease ( 21239051 29263402 26708285 29212778) Coronary heart disease ( 21971053 17554300 21378990 29615537) Coronary heart disease (SNP X SNP interaction) ( 21626137) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Esophageal squamous cell carcinoma ( 25129146) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioblastoma ( 28346443) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 21531791 19578367) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Metabolite levels ( 23823483) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 20512145 26545403) Non-glioblastoma glioma ( 28346443) Non-melanoma skin cancer ( 29739929) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Pulse pressure ( 27841878) Type 2 diabetes ( 21573907 27189021 18372903 24509480 26961502 29358691 30297969 26818947 23945395 22293688 22961080 20581827 19401414 17463246 30718926 17463248 17463249 19056611) Vertical cup-disc ratio ( 20548946)
Interacting Genes		67 interacting genes: AP5B1 APIP ARPIN BEND7 CCDC102B CCDC85B CDKN2B CDKN2C COIL COPS2 CUTC CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DUSP23 DYNLT3 EIF5A2 ENOX1 EPHB6 FXR2 GNMT GRB2 KCTD17 KRT15 KXD1 LAMTOR3 LMO2 MAGEA11 MAPRE2 MLXIPL NATD1 NME1 NOL3 NUDT14 NUDT21 ORC5 PAICS PCBD1 PNMA1 PRTFDC1 RABAC1 RAD54B RPIA S100A1 SAT1 SNF8 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SYT17 THOC7 TIFA TRAF2 TRIM21 TRIM27 TRIP13 TSC22D4 VIM YES1 YWHAQ ZBED1	54 interacting genes: AKT1 APP ARAF ARNT ARPC3 BECN1 CBLC CCDC33 CCDC90B CCND2 CCNE1 CD44 CDK4 CDK6 CDK8 CDKN2A CDKN2C CEP126 ELP1 EPHA2 ERBB2 FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A IGF1R ISL1 KAT2A KDELR2 LATS2 MAGEA11 MAP2K3 MAP2K5 MAP2K6 MDM4 MET MYC NF2 NIF3L1 PDGFRA RAF1 RASSF1 STK11 TEAD2 TERT TGFB1I1 TNFRSF1A TP53 TRAF1 TSC1 TTYH2 ZBTB17
Entrez ID		60491	1030
HPRD ID		10424	02696
Ensembl ID		ENSG00000196290	ENSG00000147883
Uniprot IDs		A0A024R3V5 A0A024R3V7 Q9GZT8	K7PPU3 P42772
PDB IDs
Enriched GO Terms of Interacting Partners?
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