CDKN2B and CDKN2C

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CDKN2B	CDKN2C
Description		cyclin dependent kinase inhibitor 2B	cyclin dependent kinase inhibitor 2C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Negative Regulation Of Cell Proliferation Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Extracellular Stimulus Cellular Response To Nutrient Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Negative Regulation Of Epithelial Cell Proliferation Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Oligodendrocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs
Diseases		Malignant pleural mesothelioma Osteosarcoma Type II diabetes mellitus
GWAS		Ankle-brachial index ( 22199011) Basal cell carcinoma ( 24403052 25855136 27539887) Breast cancer ( 29059683 23535729 20453838) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Carotid plaque burden ( 28282560) Chronic lymphocytic leukemia ( 23770605) Coronary artery calcification ( 22144573 23561647) Coronary artery disease ( 21239051 29263402 26708285 29212778) Coronary heart disease ( 21971053 17554300 21378990 29615537) Coronary heart disease (SNP X SNP interaction) ( 21626137) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Esophageal squamous cell carcinoma ( 25129146) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioblastoma ( 28346443) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 21531791 19578367) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Metabolite levels ( 23823483) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 20512145 26545403) Non-glioblastoma glioma ( 28346443) Non-melanoma skin cancer ( 29739929) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Pulse pressure ( 27841878) Type 2 diabetes ( 21573907 27189021 18372903 24509480 26961502 29358691 30297969 26818947 23945395 22293688 22961080 20581827 19401414 17463246 30718926 17463248 17463249 19056611) Vertical cup-disc ratio ( 20548946)	Atrial fibrillation ( 29290336) Height ( 31562340) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) QRS complex (12-leadsum) ( 27659466) QRS duration ( 27577874 21076409 27659466) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		54 interacting genes: AKT1 APP ARAF ARNT ARPC3 BECN1 CBLC CCDC33 CCDC90B CCND2 CCNE1 CD44 CDK4 CDK6 CDK8 CDKN2A CDKN2C CEP126 ELP1 EPHA2 ERBB2 FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A IGF1R ISL1 KAT2A KDELR2 LATS2 MAGEA11 MAP2K3 MAP2K5 MAP2K6 MDM4 MET MYC NF2 NIF3L1 PDGFRA RAF1 RASSF1 STK11 TEAD2 TERT TGFB1I1 TNFRSF1A TP53 TRAF1 TSC1 TTYH2 ZBTB17	51 interacting genes: AHCYL1 AKT1 ANGPTL4 APLP1 ARNT ATM ATR CCDC90B CCND2 CCNE1 CDK4 CDK6 CDKN2A CDKN2B COPS6 DRAP1 EPHA2 ERBB2 FGFR4 GDF9 GOPC GREB1 GRM1 LATS2 LNX2 LRIF1 LY96 MAP2K3 MAP2K5 MAPK10 MAPK8 MTA3 MYC NAGK NAT2 NF2 NIF3L1 PDGFRA PPP2CA RAF1 RBM48 REL SCGB2A2 SNU13 ST14 STK11 TCF12 TCF4 TLE1 TP53 UNC119
Entrez ID		1030	1031
HPRD ID		02696	04534
Ensembl ID		ENSG00000147883	ENSG00000123080
Uniprot IDs		K7PPU3 P42772	P42773 Q6ICV4
PDB IDs			1BU9 1G3N 1IHB 1MX2 1MX4 1MX6
Enriched GO Terms of Interacting Partners?
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